Studies of Intestinal Microflora VI. Effect of X Irradiation on the Fecal Microflora of the Rat

Klainer, Albert S.; Gorbach, Sherwood L.; Weinstein, Louis

doi:10.1128/jb.94.2.378-382.1967

Cited by 10 publications

References 10 publications

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Relation between the faecal concentration of various potentially pathogenic microorganisms and infections in individuals (mice) with severely decreased resistance to infection

Waaij

Tieleman-Speltie

Roeck-Houben

1978

Antonie van Leeuwenhoek

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Lethally irradiated conventional mice were killed at daily intervals after irradiation. A high correlation was found between the occurrence of bacterial overgrowth in the digestive tract and invasion into the regional lymph nodes the spleen and the blood. By oral contamination of mice with quite high doses of either an exogenous or an endogenous biotype of an Enterobacteriaceae species at day 4 after irradiation, it was attempted to induced such condition of intestinal overgrowth. In all animals such an abnormal colonization of the contaminant was indeed achieved in this way and the mice died from an infection caused by the biotype used for the contamination. The interval between contamination and death was different when different biotypes were used for contamination and occurred sooner after irradiation when an endogenous biotype was used for (re)contamination. It is concluded that oral contamination with exogenous as well as with endogenous potentially pathogenic bacteria during a period of severely decreased resistance to infections must be avoided. The colonization resistance of the digestive tract of these animals should be maintained as high as possible.

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Relation between the faecal concentration of various potentially pathogenic microorganisms and infections in individuals (mice) with severely decreased resistance to infection

Waaij

Tieleman-Speltie

Roeck-Houben

1978

Antonie van Leeuwenhoek

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Active components of intestinal bacteria for abdominal irradiation-induced inhibition of lung metastases

Jibu

Andō²,

Matsumoto³

et al. 1991

Clin Exp Metast

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We have previously reported that abdominal irradiation of mice inhibited lung metastases of a weakly immunogenic fibrosarcoma, and that transmigration after the irradiation of Enterobacter cloacae into mesenteric lymph nodes coincided with this phenomenon. In this paper, we show that Escherichia coli as well as E. cloacae reduce the number of metastatic lung colonies when these bacteria were intravenously injected into mice prior to the tumour cell challenge. The inhibition was caused not only by the administration of living bacteria but also by that of killed bacteria. Bacterial lipopolysaccharide (LPS), a component of membrane, replaced at least in part the effect of whole bacteria. Transfer of spleen cells from LPS-treated mice into intact recipients prominently inhibited metastatic development in the recipient mice. 'Cross transfer' between LPS high responders and LPS low responders suggested an indirect activity of transferred spleen cells. The antimetastatic activity of LPS depended on the tumour cell type; metastasis of fibrosarcomas was extensively inhibited by LPS irrespective of tumour immunogenicity while that of adenocarcinomas was only slightly inhibited. These results suggest that non-immunological mechanisms are involved in the antimetastatic activity of LPS.

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Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies

Gibson

Keefe

2006

Support Care Cancer

190

130

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Studies of Intestinal Microflora VI. Effect of X Irradiation on the Fecal Microflora of the Rat

Cited by 10 publications

References 10 publications

Relation between the faecal concentration of various potentially pathogenic microorganisms and infections in individuals (mice) with severely decreased resistance to infection

Relation between the faecal concentration of various potentially pathogenic microorganisms and infections in individuals (mice) with severely decreased resistance to infection

Active components of intestinal bacteria for abdominal irradiation-induced inhibition of lung metastases

Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies

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