Studies of Yellow Fever Virus in Tissue Culture

Haagen, E.; Theiler, Max

doi:10.3181/00379727-29-5917

Cited by 12 publications

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“…Accurate recapitulation of viral infection in a laboratory setting is critical for the dissection of virus-host interactions and ultimately for identification of potential therapeutic targets and subsequent drug development. Definition of the conditions under which cells can be maintained in culture was pioneered in the late nineteenth and early twentieth centuries (1,2) and enabled initial in vitro observation and attenuation of viruses in animal tissue cultures (3, 4). In 1949, Enders et al (5) demonstrated the ability to grow poliomyelitis virus in nonneuronal human embryonic tissues, for which they were awarded the 1954 Nobel Prize in Physiology or Medicine.…”

Section: Modeling Viral Infectionmentioning

confidence: 99%

New Methods in Tissue Engineering: Improved Models for Viral Infection

et al. 2014

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New insights in the study of virus and host biology in the context of viral infection are made possible by the development of model systems that faithfully recapitulate the in vivo viral life cycle. Standard tissue culture models lack critical emergent properties driven by cellular organization and in vivo–like function, whereas animal models suffer from limited susceptibility to relevant human viruses and make it difficult to perform detailed molecular manipulation and analysis. Tissue engineering techniques may enable virologists to create infection models that combine the facile manipulation and readouts of tissue culture with the virus-relevant complexity of animal models. Here, we review the state of the art in tissue engineering and describe how tissue engineering techniques may alleviate some common shortcomings of existing models of viral infection, with a particular emphasis on hepatotropic viruses. We then discuss possible future applications of tissue engineering to virology, including current challenges and potential solutions.

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Section: Modeling Viral Infectionmentioning

confidence: 99%

New Methods in Tissue Engineering: Improved Models for Viral Infection

et al. 2014

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“…Furthermore, he observed that repeated passages of YFV through mouse brains led to a gradual loss of virulence for rhesus monkeys [ 35 ]. The first YFV in vitro culture was achieved two years later, using Carrell dishes [ 36 ] and several kinds of tissue notably from kidneys or testicles of guinea pigs, and rabbits as well as chicken embryos [ 37 ]. Although Theiler had already made substantial contributions to the field of YFV research, his greatest achievement was the development of the vaccine strain YF 17D, through in vitro serial passages of the virulent strain Asibi (see above) in chicken embryo tissues [ 38 , 39 ].…”

Section: Introduction a Historical Perspectivementioning

confidence: 99%

What Does the Future Hold for Yellow Fever Virus? (I)

Klitting

Gould

Paupy

et al. 2018

Genes

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The recent resurgence of yellow fever virus (YFV) activity in the tropical regions of Africa and South America has sparked renewed interest in this infamous arboviral disease. Yellow fever virus had been a human plague for centuries prior to the identification of its urban transmission vector, the Aedes (Stegomyia) aegypti (Linnaeus) mosquito species, and the development of an efficient live-attenuated vaccine, the YF-17D strain. The combination of vector-control measures and vaccination campaigns drastically reduced YFV incidence in humans on many occasions, but the virus never ceased to circulate in the forest, through its sylvatic invertebrate vector(s) and vertebrate host(s). Outbreaks recently reported in Central Africa (2015–2016) and Brazil (since late 2016), reached considerable proportions in terms of spatial distribution and total numbers of cases, with multiple exports, including to China. In turn, questions about the likeliness of occurrence of large urban YFV outbreaks in the Americas or of a successful import of YFV to Asia are currently resurfacing. This two-part review describes the current state of knowledge and gaps regarding the molecular biology and transmission dynamics of YFV, along with an overview of the tools that can be used to manage the disease at individual, local and global levels.

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“…Furthermore, he observed that repeated passages of YFV through mouse brains led to a gradual loss of virulence for rhesus monkeys [35]. The first YFV in vitro culture was achieved two years later, using Carrell dishes [36] and several kinds of tissue notably from kidneys or testicles of guinea pigs and rabbits as well as chicken embryos [37]. Although Theiler had already made substantial contributions to the field of YFV research, his greatest achievement was the development of the vaccine strain YF 17D, through in vitro serial passages of the virulent strain Asibi (see above) in chicken embryo tissues [38,39].…”

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confidence: 99%

What Does the Future Hold for Yellow Fever Virus? (I)

Klitting

Fischer

Drexler

et al. 2018

Preprint

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Abstract:The recent resurgence of yellow fever virus (YFV) activity in the tropical regions of Africa and South America has sparked renewed interest in this infamous arboviral disease. YFV had been a human plague for centuries prior to the identification of its urban transmission vector, the Aedes aegypti mosquito species, and the development of an efficient live-attenuated vaccine, the YF-17D strain. The combination of vector-control measures and vaccination campaigns drastically reduced YFV incidence in humans on many occasions, but the virus never ceased to circulate in the forest, through its sylvatic invertebrate vector(s) and vertebrate host(s). Outbreaks recently reported in Central Africa (2015)(2016) and Brazil (since late 2016), reached considerable proportions in terms of spatial distribution and total numbers of cases, with multiple exports, including to China. In turn, questions regarding the likeliness of occurrence of large urban YFV outbreaks in the Americas or of a successful import of YFV to Asia are currently resurfacing. This two-part review describes the current state of knowledge and gaps regarding the molecular biology and transmission dynamics of YFV, along with an overview of the tools that can be used to manage the disease at the individual, local and global levels.

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Studies of Yellow Fever Virus in Tissue Culture

Cited by 12 publications

References 0 publications

New Methods in Tissue Engineering: Improved Models for Viral Infection

New Methods in Tissue Engineering: Improved Models for Viral Infection

What Does the Future Hold for Yellow Fever Virus? (I)

What Does the Future Hold for Yellow Fever Virus? (I)

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