Studies on 2,4-Dithioxo and 2-Thioxoimidazolidene Derivatives

Thermal fragmentation of spirodithiohydantoins: A novel route to NHCs

“…1) constitute an important class of 5-membered heterocycles with derivatives employed as antiepileptic drugs, 1,2 anti-HIV-1, 3,4 anticonvulsant, 5,6 antitumor [7][8][9] and antileishmaniasis agents, 10 as well as being important building blocks for biologically-active complex molecules. 11 Hydantoin libraries, created and evaluated to determine structure-activity relationships, 12 demonstrate the crucial importance of substitution at position 5 for pharmacological activity. 12,13 Spiro derivatives of such heterocycles have attracted special attention as potential aldose reductase inhibitors 14 or antileishmaniasis agents.…”