Studies on a new radiopaque polymeric biomaterial

Benzina, Abderazak; Kruft, Mab Marc-Anton; Bär, Fwhm; Veen, van der Fh Frederik; Bastiaansen, Cwm Cees; Heijnen, V.; Reutelingsperger, Cpm Chris; Koole, Leo Lh

doi:10.1016/0142-9612(94)90232-1

Cited by 32 publications

(23 citation statements)

References 12 publications

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“…This means that the new BPPM‐acrylic bone cement formulations are supposed to cause less adverse effects on the surrounding bone tissues, at least as far as concerning the curing temperature 8, 28–32. The T max values obtained for acrylic bone cements modified with bromine‐containing comonomer are similar with the values presented in literature for acrylic bone cements modified with iodine‐containing comonomers 7, 8, 15–17…”

Section: Resultssupporting

confidence: 83%

Radiopaque acrylic bone cements with bromine‐containing monomer

Rusu¹,

Ibănescu²,

Ichim³

et al. 2008

J of Applied Polymer Sci

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One important issue for the acrylic bone cements concerns the radiopacity, which may be achieved by different ways. In this work, a new bromine-containing acrylic monomer, the 2-(2-bromopropionyloxy) propyl methacrylate (BPPM), was synthesized and proposed to be used for providing radiopaque bone cements. Different acrylic bone cements were realized by partially replacing the methyl methacrylate (MMA) monomer phase with 5-20% w/w of BPPM-comonomer. The effect of this comonomer on the curing parameters of acrylic bone cements, on their thermal and rheological properties, water absorption, density, contact angle, compression tests, and radiopacity was studied. It appears that the presence of BPPM does provide radiopacity, improves the curing parameters by decreasing the maximum curing temperature and increasing the setting time. The new BPPM-acrylic bone cements exhibit lower glass transition temperature and better thermal stability when compared with the classical radiolucent acrylic cements. Rheological measurements have shown that 10-20% w/w of BPPM in the liquid phase of acrylic bone cement formulations increase its flexibility, and may also induce a slight crosslinking reaction during the curing phase. BPPM-modified acrylic bone cements present lower polymerization shrinkage and higher compression strength, and similar water uptake, porosity, and water contact angle as the radiolucent PMMA-cements.

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Section: Resultssupporting

confidence: 83%

Radiopaque acrylic bone cements with bromine‐containing monomer

Rusu¹,

Ibănescu²,

Ichim³

et al. 2008

J of Applied Polymer Sci

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“…This particularly is important because these drugs have a direct dose-response relationship and have reduced bioavailability as oral bisphosphonates. 7,8 Alternatives to PMMA have great appeal as local delivery media, 2,3,6,12,23,35,39,41 yet none matches the successful blend of strength, compatibility, and ability to reconstruct bone defects while delivering pertinent drugs. The Food and Drug Administration has approved PMMA for skeletal reconstruction and fixation of prostheses that are used in reconstructive orthopaedic and oncologic surgeries.…”

mentioning

confidence: 99%

PMMA to Stabilize Bone and Deliver Antineoplastic and Antiresorptive Agents

Healey¹,

Shannon²,

Boland³

et al. 2003

Clinical Orthopaedics and Related Research

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Antineoplastic and antiresorptive drugs added to polymethylmethacrylate cement may prevent local cancer progression and failure of reconstructive devices used to treat patients with pathologic fractures. We tested the mechanical properties of cement containing various amounts of the drugs and found that as much as 2 g of either doxorubicin or pamidronate can be added to Simplex cement and the cement retains 87% of its compressive and tensile strength after 6 months of wet storage. Approximately 1 mg pamidronate elutes from experimental pellets. One half of the drug elution occurs within the first day in experiments that combined doxorubicin and pamidronate, and within 3 days when pamidronate was the only additive. Cement containing these drugs seems to be strong enough, but its fatigue strength should be tested before using it clinically. Sufficient amounts of the tested drugs elute to have potential biologic activity.

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“…The monomer 4IEMA was synthesized from 4-iodobenzoyl chloride as described previously [16]. MAA, benzoyl peroxide (BPO), tetraethylene glycol dimethacrylate (TEGDMA), poly(vinyl alcohol) (PVA; MW 86000; 99-100% hydrolyzed), poly(ethylene glycol (PEG; MW 1000) and poly(vinyl pyrrolidone) (PVP; K-23-32; MW 5800) were used as purchased.…”

Section: Methodsmentioning

confidence: 99%

“…This unique feature of intrinsic radiopacity has been introduced about one decade ago for polymeric biomaterials [16][17][18][19][20]. Since then, several applications have emerged [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%