Studies on Chemistry, Spectroscopy and Antioxidant Activities of Chromium(III)-Hydrazide Complexes

Jamal, Rifat Ara; Ashiq, Uzma; Mahrooof-Tahir, Mohammad; Shaikh, Zubair A.; Sultan, Sadaf; Khan, Khalid Mohammed

doi:10.2174/1573406411666150401103442

Cited by 5 publications

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“…All ligands were dissolved at room temperature in ethanol except compound 2 and 4 that were dissolved on heating. Analytical and physical data of chromium(III) complexes (8a-12a) were discussed previously [13] while chromium (III) complexes (1a-7a) are presented in this study.…”

Section: Synthesis Of Chromium(iii) Complexes Of Aroylhydrazinesmentioning

confidence: 93%

“…All of the aroylhydrazine ligands ( Figure 1) have been synthesized and characterized previously. The physical and analytical data of these synthesized ligands have been described [7][8][9][10][11][12][13][14][15]. Aroylhydrazine ligands (1-7) were re synthesized here from previous method [13].…”

Section: Synthesis Of Aroylhydrazine Ligandsmentioning

confidence: 99%

“…Chromium(III)-aroylhydrazine complexes were synthesized using Scheme 1, 5 mmol solution of CrCl3.6H2O was dissolved in ethanol (5 mL), in the same way 10 mmol solution of suitable aroylhydrazine ligand was also dissolved in ethanol (10 mL) [13]. At room temperature mixing was done and the resulting mixture was refluxed.…”

Section: Synthesis Of Chromium(iii) Complexes Of Aroylhydrazinesmentioning

confidence: 99%

“…Synthesis and structural studies of aroylhydrazine ligands (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) have reported previously [7][8][9][10][11][12][13][14][15]. Chromium(III)-aroylhydrazine complexes (8a-12a) were discussed in reference [13] while remaining chromium(III) complexes (1a-7a) with aroylhydrazine ligands (1-7) are specified in Figure 1 and Scheme 1. In the synthesis of chromium(III)-aroyl-hydrazine complexes (1a-7a), a mixture of chromium (III) chloride using distilled ethanol were refluxed in 1:2 mole ratio with a given aroylhydrazine ligands.…”

Section: Synthesis and Physicochemical Propertiesmentioning

confidence: 99%

“…So it is necessary to investigate new non-toxic chromium(III) complexes. Moreover, ligands such as aroylhydrazines have also an enormous biologically importance and their activities are known to be more enhanced after complexation with certain metal ions [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic, antiglycation and carbonic anhydrase inhibition studies of chromium(III)-aroylhydrazine complexes

et al. 2018

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In order to further reveal the chemistry and biochemistry of chromium(III) complexes, the present work illuminates the formation of chromium(III) complexes with aroylhydrazine ligands with their physical, chemical and spectral studies. Another significant contribution of this study is the evaluation of the cytotoxic activity, antiglycation property and carbonic anhydrase inhibition study of synthesized chromium(III)-aroylhydrazine complexes. Synthesis and structural investigation of aroylhydrazine ligands (1-7) and their chromium(III) complexes (1a-7a) were carried out by using elemental analysis (C, H, N), physical (conductivity measurements) and spectral (EI-Mass, ESI-Mass, FTIR and UV-Visible) methods. These physical, analytical and spectral data supports that all chromium(III)-aroylhydrazine complexes exhibit an octahedral geometry in which ligand exhibits as a bidentate coordination and two water molecules coordinated at equatorial positions with general formula [Cr(L)2(H2O)2]Cl3. Cytotoxic investigations shows that synthesized chromium(III)-aroylhydrazine complexes were not found to be toxic against normal cells so these compounds were further studied for other biological activities. Moreover, aroylhydrazine ligands and their chromium(III) complexes were examined for their antiglycation activity in which ligands were found inactive whereas chromium(III)-aroylhydrazine complexes showed significant inhibition of the process of protein glycation. Similarly, in carbonic anhydrase inhibition studies all aroylhydrazine ligands were observed inactive while some of chromium(III)-aroylhydrazine complexes showed potential in carbonic anhydrase inhibition.

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Section: Synthesis Of Chromium(iii) Complexes Of Aroylhydrazinesmentioning

confidence: 93%

Section: Synthesis Of Aroylhydrazine Ligandsmentioning

confidence: 99%

Section: Synthesis Of Chromium(iii) Complexes Of Aroylhydrazinesmentioning

confidence: 99%

Section: Synthesis and Physicochemical Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxic, antiglycation and carbonic anhydrase inhibition studies of chromium(III)-aroylhydrazine complexes

et al. 2018

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Phthalimide‐tethered isatins as novel poly(ADP‐ribose) polymerase inhibitors: Design, synthesis, biological evaluations, and molecular modeling investigations

El Hassab,

El‐Hafeez,

Almahli

et al. 2023

Archiv der Pharmazie

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Humanity is currently facing various diseases with significant mortality rates, particularly those associated with malignancies. Numerous enzymes and proteins have been identified as highly promising targets for the treatment of cancer. The poly(ADP‐ribose) polymerases (PARPs) family comprises 17 members which are essential in DNA damage repair, allowing the survival of cancer cells. Unlike other PARP family members, PARP‐1 and, to a lesser extent, PARP‐2 show more than 90% activity in response to DNA damage. PARP‐1 levels were shown to be elevated in various tumor cells, including breast, lung, ovarian, and prostate cancer and melanomas. Accordingly, novel series of phthalimide‐tethered isatins (6a‐n, 10a‐e, and 11a‐e) were synthesized as potential PARP‐1 inhibitors endowed with anticancer activity. All the synthesized molecules were assessed against PARP‐1, where compounds 6f and 10d showed nanomolar activities with IC50 = 15.56 ± 2.85 and 13.65 ± 1.42 nM, respectively. Also, the assessment of the antiproliferative effects of the synthesized isatins was conducted on four cancer cell lines: leukemia (K‐562), liver (HepG2), and breast (MCF‐7 and HCC1937) cancers. Superiorly, compounds 6f and 10d demonstrated submicromolar IC50 values against breast cancer MCF‐7 (IC50 = 0.92 ± 0.18 and 0.67 ± 0.12 µM, respectively) and HCC1937 (IC50 = 0.88 ± 0.52 and 0.53 ± 0.11 µM, respectively) cell lines. In addition, compounds 6f and 10d induced arrest in the G2/M phase of the cell cycle as compared to untreated cells. Finally, in silico studies, including docking and molecular dynamic simulations, were performed to justify the biological results.

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Vanadium(V) complexes with hydrazides and their spectroscopic and biological properties

et al. 2017

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The present study explores the synthesis and inhibitory potential of vanadium(V) complexes of hydrazides (1c-12c) against oxidative enzymes including xanthine oxidase and lipoxygenase (LOX). In addition, non-enzymatic radical scavenging activities of these complexes were also determined. On the basis of spectral, elemental and physical data, synthesized vanadium(V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. Results show that hydrazide ligands (1-12) and their respective vanadium(V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and LOX, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds.

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Studies on Chemistry, Spectroscopy and Antioxidant Activities of Chromium(III)-Hydrazide Complexes

Cited by 5 publications

References 0 publications

Cytotoxic, antiglycation and carbonic anhydrase inhibition studies of chromium(III)-aroylhydrazine complexes

Cytotoxic, antiglycation and carbonic anhydrase inhibition studies of chromium(III)-aroylhydrazine complexes

Phthalimide‐tethered isatins as novel poly(ADP‐ribose) polymerase inhibitors: Design, synthesis, biological evaluations, and molecular modeling investigations

Vanadium(V) complexes with hydrazides and their spectroscopic and biological properties

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