Studies on Collagenase Inhibitors. II. Inhibitory Effects of Anthraquinones on Bacterial Collagenase

Tanaka, Toshiaki; Metori, Koichi; Mineo, Satoshi; Matsumoto, Hitoshi; Satoh, Toshifumi

doi:10.1248/yakushi1947.110.9_688

Cited by 12 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among 44 anthraquinones tested against bacterial collagenase in vitro, emodin proved to be the most potent active inhibitor. 122 The scientific basis of emodin's action of inhibition of metastasis first came from the study of Zhang et al 96 In a study with emodin and nine derivatives, the authors identified that one methyl, one hydroxy, and one-carbonyl functional groups are critical for the biological activities of emodin. 96 There exists a number of reports on the beneficial effects of aloe gel for healing wounds, reducing inflammation, protecting mucous membranes, and treating ulcers.…”

Section: I N H I B I T I O N O F M E T a S T A S I S B Y E M O D I Nmentioning

confidence: 99%

Molecular mechanism of emodin action: Transition from laxative ingredient to an antitumor agent

Srinivas

Babykutty

Sathiadevan

et al. 2006

Medicinal Research Reviews

262

139

View full text Add to dashboard Cite

Anthraquinones represent a large family of compounds having diverse biological properties. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Earlier studies have documented mutagenic/genotoxic effects of emodin, mainly in bacterial system. Emodin, first assigned to be a specific inhibitor of the protein tyrosine kinase p65lck, has now a number of cellular targets interacting with it. Its inhibitory effect on mammalian cell cycle modulation in specific oncogene overexpressed cells formed the basis of using this compound as an anticancer agent. Identification of apoptosis as a mechanism of elimination of cells treated with cytotoxic agents initiated new studies deciphering the mechanism of apoptosis induced by emodin. At present, its role in combination chemotherapy with standard drugs to reduce toxicity and to enhance efficacy is pursued vigorously. Its additional inhibitory effects on angiogenic and metastasis regulatory processes make emodin a sensible candidate as a specific blocker of tumor-associated events. Additionally, because of its quinone structure, emodin may interfere with electron transport process and in altering cellular redox status, which may account for its cytotoxic properties in different systems. However, there is no documentation available which reviews the biological activities of emodin, in particular, its growth inhibitory effects. This review is an attempt to analyze the biological properties of emodin, a molecule offering a broad therapeutic window, which in future may become a member of anticancer armamentarium.

show abstract

Section: I N H I B I T I O N O F M E T a S T A S I S B Y E M O D I Nmentioning

confidence: 99%

Molecular mechanism of emodin action: Transition from laxative ingredient to an antitumor agent

Srinivas

Babykutty

Sathiadevan

et al. 2006

Medicinal Research Reviews

262

139

View full text Add to dashboard Cite

show abstract

“…However, with respect to direct inhibition of the catalyt-ic activity of human MMPs no relevant reports are available. Published information merely includes a survey of the effect of several natural anthraquinones on a specific bacterial collagenase [13] or rare studies on few anthraquinone derivatives demonstrating the absence of inhibitory activity on human granulocyte gelatinase by these compounds [14]. In order to clarify this ambiguous and controversial issue, in the present study several natural anthraquinones, emodin, emodic acid, chrysazin, physcion, and rhein (• " Fig.…”

mentioning

confidence: 99%

Differential Inhibition of Matrix Metalloproteinases-2, -9, and -13 Activities by Selected Anthraquinones

Wierzchacz¹,

Su²,

Kolander³

et al. 2009

Planta Med

View full text Add to dashboard Cite

Matrix metalloproteinases (MMPs) play an important role in physiological and pathological matrix remodeling. Here, we report that the natural anthraquinones, emodin, emodic acid, chrysazin, physcion, and rhein differentially inhibit several members of this enzyme family, the gelatinases MMP-2 and -9, and the collagenase MMP-13. The IC50 values determined by measuring the activities of human recombinant catalytic domains of these enzymes varied in the micromolar range. Emodin and emodic acid most potently inhibited MMP-9 with IC50 values of 15 and 10 microM, respectively. With MMP-13, emodic acid was 3-times less potent than emodin which showed a similar IC50 value (13 microM) as chrysazin. These results are of interest in view of the widespread medicinal use of anthraquinones and their derivatives.

show abstract

“…There are numerous reports suggesting the antimetastatic property of emodin in tumor cells. Among the 44 anthraquinones tested against bacterial collagenase in vitro, emodin proved to be the most potent active inhibitor [15]. Therefore, elucidation of critical pathways in metastasis where emodin could exert its inhibitory effects should make it a perfect fit for antitumor therapy.…”

Section: Discussionmentioning

confidence: 99%

Expression of MMP2 and MMP9 (Gelatinases A and B) in Human Colon Cancer Cells

Damodharan

Ravikumar

Radhakrishnan

2011

Appl Biochem Biotechnol

View full text Add to dashboard Cite

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, collectively capable of degrading essentially all matrix components. Elevated levels of distinct MMPs are detected in tumor tissue or serum of patients with advanced cancer, and they are the major prognostic indicators in cancer. Inhibition of MMPs has been explored as a therapeutic goal for almost two decades. Nitric oxide (NO), a free radical plays an important role in signaling pathways in regulation of MMP expression. In the present study, we demonstrated the role of exogenous NO levels in the regulation of MMP2 and MMP9 (gelatinases A and B) in colon cancer cell line WiDr and its inhibition with emodin (a naturally occurring anthraquinone).

show abstract

Studies on Collagenase Inhibitors. II. Inhibitory Effects of Anthraquinones on Bacterial Collagenase

Cited by 12 publications

References 0 publications

Molecular mechanism of emodin action: Transition from laxative ingredient to an antitumor agent

Molecular mechanism of emodin action: Transition from laxative ingredient to an antitumor agent

Differential Inhibition of Matrix Metalloproteinases-2, -9, and -13 Activities by Selected Anthraquinones

Expression of MMP2 and MMP9 (Gelatinases A and B) in Human Colon Cancer Cells

Contact Info

Product

Resources

About