Studies on correlations between chloroquine-induced tissue damage and serum enzyme changes in the rat

Abstract

The administration of chloroquine to rats resulted in a significant elevation of serum enzymes and a corresponding decrease of these enzymes in the tissues. The changes in serum and kidney enzymes were most marked, thus indicating a primary renal dysfunction.

Hepatoprotective effects of Garcinia kola seed against hepatotoxicity induced by carbon tetrachloride in rats

“…5 who reported elevated levels in the serum content of hepatic enzymes in rats administered with CC1 4 . In particular, the elevation of ALT is indicative of liver damage 12,13 . These enzymes are located in the cell cytoplasm and are emptied into the circulation once the cellular membrane is damaged 14,15 .…”

Biochemical changes in the liver, kidney and serum of rat following chronic administration of cimetidine

“…The methods of Akanji and Ngaha (1989), Ngaha et al (1989) and Akanji and Yakubu (2000) were used. Briefly, under diethyl ether anesthesia, the neck areas were quickly cleared of fur and skin to expose the jugular veins.…”

Assessment of the Effect of Cannabis sativa and Nicotiana tobacumLeaves on some Haematological and Liver Function Indices of Albino Rats.

“…Total protein concentration of the samples was assayed by the Biuret method [18]. All other reagents used were of analytical grade and were prepared in glass distilled water.…”

“…The coagulated blood was then centrifuged at 3000 rpm for 5 minutes to give a clear supernatant (serum) which was aspirated with Pasteur pipette, store in sample bottles and used within 12 hours of preparation. Each of the organs was cut with a clean sterile blade and then homogenized in ice-cold 0.25M sucrose solution 1:5 w/v [18]. The homogenate were kept frozen over night at 20°c before being used for the biochemical assay.…”