Studies on development and characterization of gastroretentive drug delivery system for antibiotics: Cefdinir

Garrepally, Prasad; Gonugunta, Chandra Sekhara Rao

doi:10.1016/j.jopr.2013.08.011

Cited by 3 publications

(5 citation statements)

References 26 publications

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“…It was measured using Monsanto hardness tester by measuring 6 tablets from each batch and take the average (10). The results were presented as mean ± SD.…”

Section: Hardness Testmentioning

confidence: 99%

“…NFT (8,9,10) which contain HPMC K4M in three different concentrations 59%, 48% , 37% (w/w) respectively of the total weight of the tablet were used to study the polymer concentration on the floating behavior and drug release from cefdinir lyophilized floating tablet.…”

Section: Formulasmentioning

confidence: 99%

“…MCC(PH102) was used as a binder agent in NFT(1-5) formulations only. On the other hand, PVP K30 was used a binder in NFT (6)(7)(8)(9)(10)(11)(12) formulations.…”

Section: Table (4): Disintegration Time Of Immediate Release Layermentioning

confidence: 99%

“…The bilayer tablet is an unique method for the effective and promising of controlled delivery design through many ways to deliver an effective drug transport system. The benefits of a bilayer tablet continue to outweigh the shortcomings of a singlelayered tablet (10). The physical and chemical properties of the chemicals in the formulation, the interaction between the components in addition to the porosity, swelling, and tablet erosion are all significant factors that affect drug release in a bilayer tablet.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and characterization of floating biphasic tablet consisting of cefdinir nanosuspension

Al-Mahmood

Alhammid

2022

ijhs

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Cefdinir (Cef) is a third-generation cephalosporin antibacterial agent with an extended spectrum and low solubility and permeability. In this study, cefdinir was prepared as nanosuspension and lyophilized to powder. The lyophilized cefdinir was further processed to develop a bilayer tablet. By utilizing the bilayer approach, the first therapeutic action is impacted by the immediate part's rapid disintegration and a prolonged release from the floating part is achieved. Floating system ensures a recognized extended-release in the gastric medium and avoids the numerous daily dosages. Different polymers were utilized with effervescent materials in different concentrations. The method employed in preparing tablets is direct compression. Every formulation undergoes through standard pre and post-compression floating tablet characteristics with unique results that allow for further comparison between various formulations and increase our understanding of the makeup of medications, polymers, additives, and preparation technique. The formula NFT8 was selected as the best formulation design. It contains (HPMC K4M 400 mg, Carbapol940 50 mg, sodium bicarbonate 100 mg, and citric acid 75 mg) and provided efficient floating characteristics for more than 24 hr as revealed by in vitro dissolution release.

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“…It was measured using Monsanto hardness tester by measuring 6 tablets from each batch and take the average (10). The results were presented as mean ± SD.…”

Section: Hardness Testmentioning

confidence: 99%

Section: Formulasmentioning

confidence: 99%

“…MCC(PH102) was used as a binder agent in NFT(1-5) formulations only. On the other hand, PVP K30 was used a binder in NFT (6)(7)(8)(9)(10)(11)(12) formulations.…”

Section: Table (4): Disintegration Time Of Immediate Release Layermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Formulation and characterization of floating biphasic tablet consisting of cefdinir nanosuspension

Al-Mahmood

Alhammid

2022

ijhs

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“…Sefdi-nirin iki tabakalı tablet teknolojisi kullanılarak yeni bir midede kalan tablet formülasyonu geliştirilmiş ve ikinci tabakadaki matriksten 0. derece salım kinetiğiyle etkin madde salımı sağlanmıştır. 12 Teofilinin farklı formülasyonları efervesan olarak merkezi kompozit tasarım ile hazırlanmış ve etkin maddenin salımı başarılı bir şekilde 8 saat kontrol edilebilmiştir. 13 Model etkin madde olarak losartan potasyumun efervesan yöntemle hazırlanmış midede yüzen tabletlerinin hazırlandığı çalışmada; tabletlerin sürekli salım yaparak, midede uzun süre kalabildiği gösterilmiştir.…”

Section: İntestinal Ve Kolonik Ortamlarda Stabil Olmayan Etkin Maddelerunclassified

Pharmaceutical Approach to the Floating/Gastroretentive Systems in Stomach

Özsoy¹,

Özçelik²

2018

J Lit Pharm Sci

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Ö ÖZ ZE ET T Uzatılmış oral etkin madde salım sistemleri; doz sıklığındaki azalma, plazma konsantrasyon seviyesindeki dalgalanmaların azalması ve artan hasta uyuncu nedeni ile oldukça ilgi çeken sistemlerdir. Bu sistemler içinde yer alan yüzen sistemler eğer kısa gastrik kalış süresi ve beklenmeyen gastrik boşalma zamanı sorunları başarıyla halledilebilir ise son derece umut verici yaklaşımlardır. Bu sistemlerle, üst gastrointestinal bölgede emilimleri kısıtlı ve biyoyararlanımı düşük etkin maddeler için emilimlerinin artırılmasına bağlı olarak; etkinliklerinin artırılması, bazı durumlarda klinik dezavantajlarının dengelenebilmesi, mide ve duodenal ülserlerin tedavisinde yararlı stratejiler oluşturabilme ve bölgeye spesifik etkin madde uygulanabilme gibi faydalar sağlanabilmektedir. Bu tip ilaç şekillerinin geliştirilmesi sırasında, ilaç şeklinin istenilen ve yeterli periyotta midede kalabilmesinin zor olması, terapötik çeşitlilik içinde etkin maddenin emiliminin tamamlanamaması gibi zorluklarla karşılaşılmakla beraber, gelişime açık olmalarına engel olamamıştır. Bu sistemler, dansite kontrolü sağlanarak gastrik içerikte kalabilmelerinden dolayı uzatılmış zaman periyodunda gastrik boşalma zamanından etkilenmemektedirler. Buna bağlı olarak, gastrik geçiş zamanı arttığından plazma etkin madde konsantrasyonundaki dalgalanmaların daha iyi kontrol edilebilmesi sağlanmaktadır. Dolayısıyla yüzen ilaç şekillerine, biyoadeziv ilaç şekillerine, raft (sal) formundaki sistemlere, şişen ve genişleyen midede kalabilen ilaç şekillerine artan bir ilgi bulunmaktadır. Bu tarz sistemler, midede yüzerek uzun süre kalmayı ve etkin madde salımını uzatmayla beraber plazma etkin madde seviyesindeki dalgalanmaların daha iyi kontrol edilmesine olanak verebilmektedir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Gastrointestinal kanal; gecikmeli hazırlıklar; ilaç dağıtım sistemleri A AB BS S T TR RA AC CT T Extended drug delivery systems are increasingly attracted due to reduction in dose frequency, decreasing of fluctuations in plasma concentration level and raising patient compliance. Floating systems are the part of in these systems and extremely hopeful approaches if low gastric residence time and unexpectable gastric emptying time problems are able to solve. Especially for the drugs which have the low absorption in upper gastrointestine and low bioavailability are increased their effectiveness by increased absorption, balancing of clinical disadvantages in some stuations, be able to create useful strategies for the treatment of gastritis and duodenal ulcers and it is possible to provide benefits about drug application to the specific region. During the development of such dosage forms, it is difficult to remain in the desired and adequate period, and with difficulties such as the inability to complete absorption of the drug in therapeutic diversity but their development did not prevent from being open for improvement. Because these systems can maintain in gastric content by providing density control, so they are not affecte...

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Sustained delivery of cefdinir to upper gastrointestinal tract using calcium alginate beads: a formulation by design

Radhakrishnan

Singh

Verma

et al. 2014

Journal of Pharmaceutical Investigation

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Studies on development and characterization of gastroretentive drug delivery system for antibiotics: Cefdinir

Cited by 3 publications

References 26 publications

Formulation and characterization of floating biphasic tablet consisting of cefdinir nanosuspension

Formulation and characterization of floating biphasic tablet consisting of cefdinir nanosuspension

Pharmaceutical Approach to the Floating/Gastroretentive Systems in Stomach

Sustained delivery of cefdinir to upper gastrointestinal tract using calcium alginate beads: a formulation by design

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