Studies on Heterocyclic Ketenethioacetal Derivatives. III. Syntheses of Enaminodithiocarboxylates and Their Conversion into Ketenethioacetal Derivatives

Synthesis and Antileukemic Activity of 2-(2-Methylthio-2-aminovinyl)-1-methylquinolinium Iodides

“…Although there are several procedures published for the determination of I in biological fluids (3)(4)(5)(6)(7)(8), there are only two other published methods for its determination in the pharmaceutical dosage form. Davidson (9), proposed a GLC analysis, accepted by the AOAC (lo), and that uses 1,3-dichloro-2-propanol as an internal standard; a standard deviation range of 1.3-2.9% on assays of known solutions and the 500-mg capsule dosage form is reported.…”

6-Substituted l-Methylquinolinium-2-dithioacetic Acid Zwitterions: Antileukemia Activity

“…Preparations of the his(S-methyl) derivatives of dithio acids were reported (9,10). With the 6-bromo-1-methylquinolinium-2-dithioacetic acid zwitterion, treatment with excess iodomethane gave a bis(S-methyl) derivative (V, R = Rr) whose NMR spectrum showed five ring protons a t 8 8.2-9.0 ppm, N-methyl protons a t 6 4.35 ppm, S-methyl protons a t 6 2.50 and 2.63 ppm, and a one-proton singlet at d 6.65 ppm for the olefinic proton.…”