Studies on Sendai Virus Infection in Laboratory Mice

Experimental Study on the Transmission of Sendai Virus in Specific Pathogen-free Mice

“…Thus, the virus has been considered to be primarily pneumotropic and one of the agents causing respiratory virus diseases in mice. However, while intranasal inoculation of laboratory virus strains caused death in young adult mice with higher dose and in suckling mice with a smaller dose, the disease is clinically inapparent in adult mice (Sawicki, I96r, I962;Fukumi et al 1962;van Nunen & van der Veen, I968;Murata & Iida, I969). This behaviour of Sendai virus hampered experimental approaches to reveal the mode of virus infection, immunity, transmission, persistence of infection and reinfection in mice until specific pathogen-free mouse colony became available.…”

Serological Survey of Laboratory Rodents for Infection With Sendai Virus, Mouse Hepatitis Virus, Reovirus Type 3 and Mouse Adenovirus

“…Serological checking of laboratory animals for infection with murine indigenous viruses has been reported in the United States (Parker, Tennant and Ward, 1966;Parker, Hercules and von Kaenel, 1967), Japan (Fukumi et al, 1962;Fuj iwara, 1971;Fuj iwara, Tanishima and Tanaka, 1979) and the United Kingdom (Carthew and Verstraete, 1978). To scrutinize the status of murine virus infections among laboratory rodents in Japan, animals from commercial breeders and various research institutions including this institute have been examined serologically since 1973.…”

Intrauterine transmission of Sendai virus in inbred mouse strains

“…The results of this study indicate that the inbred strains of mice studied are more susceptible to the lethal effects of Sendai virus infection than are randomly bred strains such as Swiss white. Most workers have not been able to isolate Sendai virus from infected adult mouse organs beyond 12 days postinfection (2,5,9,11,13), but the inbred strains used in this study yielded infectious virus 21 days postinfection in the presence of hemagglutination inhibition antibodies.…”

“…In general, it can be seen that a higher incidence of virus isolation was obtained when mothers were infected at 11 days of gestation than at the earlier periods. In relation to the incidence of runting, the incidence of virus iso- 5 (38) 0.01-0.001 a Runting was selected as 30% below the average weight of uninfected controls for black and brown embryos at 16 days of gestation and 20% below the control weights for black newborns. Runted brown and control newborns were selected as 20% below the average weight of litters.…”