Studies on the avian shell gland during egg formation: The effect of acetazolamide on the composition of the mucosa

Mongin, Pierre

doi:10.1080/00071667808416506

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…On one side a direct relation between bicarbonate secretion and chloride absorption was assumed (Mongin and Carter, 1977), whereas a correlation between the blockage of carbonic anhydrase by acetazolamide and Ca 2+ secretion was described (Pearson and Goldner, 1974;Pearson et al, 1977;Mongin, 1978).…”

Section: Introductionmentioning

confidence: 99%

Regulation of anion transport across the uterine epithelium ofGallus domesticus

Brockmeier

Schultheiß

2011

Poultry Science

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For egg shell production, cations, primarily Ca(2+), and anions, primarily HCO(3)(-), must be secreted across the uterine epithelium. Because alterations of HCO(3)(-) transport influence Ca(2+) secretion, the present study was performed to gain insight into the regulation of anion transport (i.e., chloride and HCO(3)(-) transport) across the egg shell gland of the domestic chicken. To this purpose, unstripped uterus epithelia were mounted in modified Ussing chambers and electrogenic [i.e., short circuit current (I(sc))] and electroneutral anion transport were measured. Stimulating adenylate cyclases by forskolin, thereby enhancing the intracellular cyclic adenosine monophosphate( )(cAMP) concentration, evoked 2 patterns of I(sc) responses. Under HCO(3)(-)-buffered conditions, some of the tissues (3/8) showed an increase of I(sc), whereas in others (5/8) a decrease of I(sc) was observed in the presence of the drug. The I(sc) increase existed in HCO(3)(-) secretion because under HCO(3)(-)-free conditions forskolin stimulated only an I(sc) decrease. In addition, methazolamide, a blocker of carboanhydrases, significantly reduced baseline I(sc). The forskolin-induced decrease of I(sc) presented a Cl(-) absorption. In the absence of HCO(3)(-), forskolin yielded only an I(sc) decrease and the transepithelial flux of (36)Cl(-) was reduced. In the presence of mucosal 5-nitro-2-(3-phenylpropylamino) benzoic acid, a nonselective blocker of chloride channels, forskolin-induced I(sc) decrease was inhibited. In addition to cAMP, the regulatory influence of neurons or prostaglandins on baseline I(sc) and anion transport was investigated. Neither tetrodotoxin, a blocker of neuronal Na(+) conductances, electrical field stimulation, nor indomethacin, a blocker of cyclooxygenases, influenced the baseline I(sc) or anion transport. In summary, these data show effects of forskolin (i.e., cAMP) on anion transport across the egg shell gland of the domestic chicken: HCO(3)(-) secretion (supporting Ca(2+) mineralizing of the egg shell) and Cl(-) absorption. Neurons or prostaglandins did not influence the anion transport.

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Section: Introductionmentioning

confidence: 99%

Regulation of anion transport across the uterine epithelium ofGallus domesticus

Brockmeier

Schultheiß

2011

Poultry Science

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Calcium transport in strongly calcifying laying birds: Mechanisms and regulation

Bär

2009

Comparative Biochemistry and Physiology Part A: Molecular &

141

109

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Studies on the avian shell gland during egg formation: The effect of acetazol‐amide on the transfer of ions to the albumen¹

Sauveur

Mongin

1978

British Poultry Science

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Twenty-five laying hens were fed on a diet containing 100 mg acetazolamide/kg in order to determine the effects of a decrease in the activity of carbonic anhydrase on the transfer of minerals to the egg albumen. Treatment with acetazolamide decreased the rate of shell formation by 44%; reduced the concentrations of water and Na+ in the albumen at the beginning of the plumping stage but increased the accumulation of water during plumping; increased the concentration of Cl- in the albumen after the 6-h stage without any appreciable change in K+ and Ca2+ concentrations. The computed relationships between the concentrations of different ions also showed that the transfer of water and Na+ were linked during egg formation, that a water-independent, acetazolamide-sensitive reabsorption of Na+ occurred after the 10-h stage and that Na+ and Cl- moved simultaneously up to 14 h but with the ratio of Cl- to Na+ three times higher in the treated group. It is concluded that acetazolamide impairs the transfer of Na+ and Cl- between the albumen and the extracellular fluid and that secretion of Ca2+ into the uterine lumen seems to depend on Na+ and Cl- reabsorption.

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Studies on the avian shell gland during egg formation: The effect of acetazolamide on the composition of the mucosa

Cited by 3 publications

References 6 publications

Regulation of anion transport across the uterine epithelium ofGallus domesticus

Regulation of anion transport across the uterine epithelium ofGallus domesticus

Calcium transport in strongly calcifying laying birds: Mechanisms and regulation

Studies on the avian shell gland during egg formation: The effect of acetazol‐amide on the transfer of ions to the albumen¹

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Studies on the avian shell gland during egg formation: The effect of acetazolamide on the composition of the mucosa

Cited by 3 publications

References 6 publications

Regulation of anion transport across the uterine epithelium ofGallus domesticus

Regulation of anion transport across the uterine epithelium ofGallus domesticus

Calcium transport in strongly calcifying laying birds: Mechanisms and regulation

Studies on the avian shell gland during egg formation: The effect of acetazol‐amide on the transfer of ions to the albumen1

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Studies on the avian shell gland during egg formation: The effect of acetazol‐amide on the transfer of ions to the albumen¹