Studies on the Constituents of Roots ofScutellaria planipes

Abstract

From the roots of Scutellaria planipes (L.), three new flavonoids, 5,7,3',6'-tetrahydroxy-6,8,2'-trimethoxyflavone, (2 R,3 R)-3,5,7,2',5'-pentahydroxyflavanone and 7,2'-dihydroxy-5-methoxyflavone were isolated, together with ten known flavonoids, skullcapflavone I, wogonin, baicalein, norwogonin, viscidulin III, 5,7,2',6'-tetrahydroxy-flavone, 3,5,7,2',6'-pentahydroxyflavone, wogonin 7- O-beta- D-glucuronide, baicalin, baicalein 7- O-beta- D-glucopyranoside, and three phenethyl alcohol glycosides, acteoside, martynoside, and jionoside D. The structures were elucidated by spectroscopic methods.

Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy

“…Compound 17 showed an [M–H] − ion at m/z 507, 162 Da greater than viscidulin III. It yielded similar fragments to compound 26, and was tentatively identified as the known viscidulin III 2′‐ O ‐glucoside 24, 25. Compound 10 showed an [M–H] − ion at m/z 303.…”

Local Differentiation of Sugar Donor Specificity of Flavonoid Glycosyltransferase in Lamiales

“…However, specific plant lineages have characteristic flavonoids conjugated with specific sugar moieties as their specialized metabolites. Flavonoid 7-Oglucuronide is commonly observed with flavonoid 7-O-glucoside in plants within the Lamiales order, such as Perilla frutescens (dietary herb), Antirrhinum majus (snapdragon flower), and Scutellaria baicalensis (a plant whose dried roots are used in Chinese natural medicine) (Figure 1) (Harborne, 1963;Asen et al, 1972;Subramanian and Nair, 1973;Abdalla et al, 1983;Tomimori et al, 1984;Kawasaki et al, 1988;Yoshida et al, 1993;Zhang et al, 1997;Hirotani et al, 1998;Harborne and Baxter, 1999;Huang et al, 1999;Yamazaki et al, 2003;Bremer et al, 2003;APG II, 2003, Wortley et al, 2005. Baicalin, a flavone 7-Oglucuronide, is predominantly accumulated in Scutellaria roots and has been well studied due to its beneficial effects on human health, such as its anti-allergic, antiviral, anti-inflammatory, and intestinal a-glucosidase inhibitory properties (Shibata and Hattori, 1931;Kida et al, 1982;Nishioka et al, 1998;Gao et al, 1999;Chou et al, 2003).…”

A urine metabonomics study of chronic renal failure and intervention effects of total aglycone extracts of Scutellaria baicalensis in 5/6 nephrectomy rats

“…6 It is listed in the Pharmacopoeia of the People's Republic of China and mainly contains avonoids such as baicalin, wogonoside, baicalein, wogonin and oroxylin A. [7][8][9] Radix Scutellariae also has a higher content of glycosides (also known as baicalin, wogonoside, etc.) than that of aglycones (also known as baicalein, wogonin, etc.).…”