Studies on the effects of unconjugated dihydroxy bile salts on rat small intestinal function in vivo

Sladen, G. E.; Harries, J T

doi:10.1016/0005-2736(72)90265-9

Cited by 62 publications

(40 citation statements)

References 17 publications

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“…Net water and solute movements were calculated by standard formulas from the changes in PEG concentrations and solute concentrations between perfusion solutions and collected samples (21 Absorption of monosaccharides. As in previous studies (8,9,(11)(12)(13)16), absorption of glucose and xylose decreased whenever absorption changed to net fluid secretion in the presence of dihydroxy bile acids or fatty acids (Figs. 1, 2, and 3).…”

Section: Methodssupporting

confidence: 78%

“…Our studies demonstrate that dihydroxy bile acids inhibit the absorption of fatty acids in addition to their established inhibitory effects on water transport and on absorption of nonmicellar solutes (8)(9)(10)(11)(12)(13)(14)(15)(16). They further document that the fractional absorption of fatty acids decreases with increasing fatty acid load and that this decrease correlates well with the simultaneously observed changes in glucose absorption and net water movement.…”

Section: Discussionsupporting

confidence: 70%

“…Dihydroxy bile acids and long-chain fatty acids induce net fluid secretion when perfused through the intestine of experimental animals (8)(9)(10)(11) and man (12)(13)(14). When water secretion is induced, electrolytes are secreted in parallel (9,11,(13)(14)(15), and in addition, absorption of organic solutes is reduced.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…When water secretion is induced, electrolytes are secreted in parallel (9,11,(13)(14)(15), and in addition, absorption of organic solutes is reduced. Dihydroxy bile acids inhibit the absorption of glucose (8,9,12,13) and amino acids (10). Oleic acid (OA) inhibits the absorption of glucose (16); and ricinoleic acid (RA), a hydroxy fatty acid, inhibits the absorption of sugars (11,16), amino acids (16), taurocholate (11), and a lipid, 2-mono-olein (16).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.

Wanitschke¹,

Ammon²

1978

J. Clin. Invest.

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Section: Methodssupporting

confidence: 78%

Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.

Wanitschke¹,

Ammon²

1978

J. Clin. Invest.

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The effects of pure and micellae solutions of different bile salts on mucosal morphology in rat jejunum in vivo

Keeling¹,

Lamabadusuriya²,

Harries³

1976

The Journal of Pathology

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The effects of pure and micellar solutions of different bile salts on mucosal morphology have been investigated in rat jejunum using a closed-loop technique; the effects of an anionic dihydroxy steroid antibiotic, fusidic acid, have also been studied. Mucosal changes were assessed by light-microscopical appearances and quantified by determining surface to volume ratios (c/1h). The unconjugated dihydroxy bile salts, chenodeoxycholate and deoxycholate (DC), produced similar and gross structural changes at concentrations of 2-5 to 5 mM, as judged by mucosal appearances, but not at 1 mM; the unconjugated trihydroxy bile salt cholate and a variety of di- and trihydroxy conjugated salts produced no changes at concentrations of 5 to 20 mM. Fusidate (5 mM) produced similar changes to 5 mM DC. Compared with control values DC (1,2-5 and 5 mM) and fusidate (5 mM) produced highly significant (P less than 0-001) reductions in c/1h ratios. DC-induced damage was completely abolished by mixed micellar solutions, whereas pure micellar solutions provided no protection. These results indicate, (i) a molecular specificity for bile salt-induced mucosal damage, and (ii) that the effects of the unconjugated dihydroxy species on mucosal structure depends not only on their intraluminal concentrations, but also on the relative concentrations of conjugated bile salts and lipids present in the lumen.

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Dietary Fiber and Intestinal Adaptation

Vahouny

Cassidy

1986

Dietary Fiber

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Studies on the effects of unconjugated dihydroxy bile salts on rat small intestinal function in vivo

Cited by 62 publications

References 17 publications

Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.

Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.

The effects of pure and micellae solutions of different bile salts on mucosal morphology in rat jejunum in vivo

Dietary Fiber and Intestinal Adaptation

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