Studies on the mechanism of iodination by the thyroid gland: Iodide-activating enzyme and an intracellular inhibitor of iodination

Suzuki, Mitsuo; Nagashima, Masao; Yamamoto, Kunihiro

doi:10.1016/0016-6480(61)90038-7

Cited by 39 publications

(3 citation statements)

References 14 publications

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“…Addition of ascorbic acid to the undialysed enzyme preparation causes inhibition of iodination due to its reducing power, as has been reported earlier [Klebonoff et al, 1962]. In fact Suzuki et al [1961] found that more than 90 per cent of the total ascorbic acid in pig thyroid occurs in the reduced form. Further work on this enzyme and on the characterization of the inhibitor are now in progress.…”

Section: Discussionsupporting

confidence: 66%

Studies on the in vitro formation of monoiodotyrosine by soluble supernatant of pigeon thyroid gland

Bhattacharya¹,

Ag²

1971

Reproduction

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Section: Discussionsupporting

confidence: 66%

Studies on the in vitro formation of monoiodotyrosine by soluble supernatant of pigeon thyroid gland

Bhattacharya¹,

Ag²

1971

Reproduction

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“…Since ascorbic acid has been suggested to play a physiological role in the regulation of iodination reactions in the thyroid (45) and is involved in the synthesis of collagen (37) which plays a key role in the maintenance of structural integrity, calcium oxalate may be a metabolite of ascorbate metabolism. Calcium oxalate may also control the intracellular calcium metabolism of the thyroid cells.…”

Section: Discussionmentioning

confidence: 99%

Oxalate in the Human Thyroid Gland

Wahl

Fuchs²,

Kallee³

1993

Clinical Chemistry and Laboratory Medicine

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Summary: Ninety-seven fixed surgical thyroid specimens and 63 unfixed and 40 fixed thyroid specimens from autopsies were examined for their oxalate content. Proteases were used to process the tissue, and the oxalate was determined with an enzymatic assay. The fixed samples were grouped into seven diagnostic categories (diffuse colloid goitre; partially diffuse, partially nodular colloid goitre; nodular colloid goitre; goitre with multifocal functional autonomy; non-functioning adenoma; unifocal functional autonomy; Graves' disease). The oxalate concentrations of the samples were mainly dependent on age and gender, which were distributed unequally among the seven diagnostic groups. In thyroid tissue from cases of Graves' disease, however, the concentration of oxalate was remarkably low and statistically different from those of four of the six other groups.

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“…50 filter paper for ascending chromatography in a solvent system of butanol, dioxane and 2 n . NH4OH (40 : 10 : 20) (21). The deter mination of radioactive compounds on paper chromatograms was executed by means of a well scintillation counter.…”

Section: Chemical Analysis Of Lp Preparationsmentioning

confidence: 99%