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A 29-year-old man developed atopic bronchial asthma in association with eosinophilia and hyperimmunoglobulinemia E (hyper-IgE). A biopsy specimen from an inguinal lymph node showed changes consistent with Kimura's disease. IPD-1151T (suplatast tosilate), an anti-allergy drug, attenuated eosinophilia and hyper-IgE as well as the serum level ofeosinophil cationic protein (ECP). The drug, however, did not affect the positivity for specific IgE antibodies against common allergens or the bronchial hyperresponsiveness to acetylcholine. Interleukin (IL)-2, IL-4, IL-5, interferon (IFN)-y, and tumor necrosis factor (TNF)-oc were measured to be undetectable in serum before or during therapy. However, the expressions of mRNAsfor IL-2, IL-4, IL-5, IFN-y, and TNF-a in peripheral blood T-lymphocytes and the expression of IL-5 mRNA in peripheral blood eosinophils were detected before and during therapy, which were unchanged by therapy with IPD-1151T. The present results suggest that different mechanisms other than the predominance of type 2 helper (TH2)-like T-lymphocytes may underlie Kimura's disease and atopic bronchial asthma regarding the findings of eosinophilia and hyper-IgE, which could be modulated by IPD-1151T.

In the course of our screening program for new antifungal antibiotics, a fungal strain F29602 was found to produce a new antifungal antibiotic, BE-29602 (1), which belonged to the family of Papulacandin. This strain, F29602, was isolated from a soil sample collected in Saitama Prefecture, Japan. Based on the cultural and morphological characteristics, strain F29602 was identified as belonging to the genus Fusarium. The strain F29602 was deposited at the National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology, Japan (No. FERM P-12503). This paper describes the fermentation, isolation, structure elucidation and biological properties of 1. Spores of strain F29602 grown on agar slant medium were inoculated into four 500-ml conical flasks, each containing 110ml of a medium (pH 6.0) comprising of glucose 1.0%, maltose 3.0%, polypeptone 0.3%, wheat germ 1.0%, corn gluten meal 0.5%, malt extract 0.3%, NaCl 0.2%,

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