2021
DOI: 10.1016/j.phyplu.2020.100018
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Studies on the mechanism of anti-inflammatory action of swietenine, a tetranortriterpenoid isolated from Swietenia macrophylla seeds

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Cited by 13 publications
(15 citation statements)
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“… [28] The expression of these two genes (NQO1 and HO‐1) depends upon NRF2 activation. [ 29 , 30 ] The mRNA levels of the genes were quantified using the 2 −ΔΔCt method [31] with β‐actin as a reference gene. The ability of THBTs (at 50 μ m ) to disrupt NRF2 and KEAP1 interaction via the kelch domain of KEAP1 was assessed using a commercially available fluorescence polarisation assay kit.…”
Section: Resultsmentioning
confidence: 99%
“… [28] The expression of these two genes (NQO1 and HO‐1) depends upon NRF2 activation. [ 29 , 30 ] The mRNA levels of the genes were quantified using the 2 −ΔΔCt method [31] with β‐actin as a reference gene. The ability of THBTs (at 50 μ m ) to disrupt NRF2 and KEAP1 interaction via the kelch domain of KEAP1 was assessed using a commercially available fluorescence polarisation assay kit.…”
Section: Resultsmentioning
confidence: 99%
“…A previous study has shown that choline and aspirin together can suppress the pro-inflammatory mediators against acute inflammation induced by carrageenan and lipopolysaccharide [ 39 ]. Other phytochemicals, bumetanide [ 40 ], fenofibrate [ 41 ] and swietenine [ 42 ] are also reported to possess anti-inflammatory activity via downregulation of pro-inflammatory cytokines. Another study documented that methanolic extract Sideritis bilgeriana suppressed TNF-α, IL-1β and leukocyte migration in carrageenan-induced pleurisy model, which is due to the presence of f phenolic and flavonoids content [ 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…The metabolic stability of the test compounds in human, rat, and mouse liver microsomes was determined using the method described in our previous work [ 8 ]. Five microlitres of auranamide or patriscabratine (0.5 µM) were incubated in a reaction mixture at 37 °C for 0, 3, 6, 15, 30, 45 and 60 min.…”
Section: Methodsmentioning
confidence: 99%
“…The heterodimer activates the antioxidant response element (ARE) to produce a number of genes encoding for detoxifying enzymes, drug transporters, anti-apoptotic proteins and proteasomal subunits [ 5 , 6 , 7 ]. NAD(P)H: oxidoreductase 1 (NQO1) and hemeoxygenase (HO)-1 are the classical markers of NRF2 activation [ 8 ]. Because of the therapeutic importance of NRF2, many researchers in academia and industry have worked on developing drugs targeting NRF2 activation [ 1 , 8 , 9 , 10 , 11 , 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
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