Studies on the Relationship of Structure to Antimicrobial Properties of Diterpenoid Compounds fromSideritis

Abstract

As a result of a study of antimicrobial agents from Spanish Sideritis species, we now report a series of natural and semisynthetic diterpenoid compounds with selective antimicrobial activity toward Gram-positive bacteria and, in some cases, also toward yeasts. A 1,3diolic group is responsible for this activity. Another hydroxyl group on the molecule produces a drastic decrease in antimicrobial activity. On the other hand, an acetoxyl group increases the inhibitory action. To the best of our knowledge, 1-acetyljativatriol (2) is the first natural entbeyerenic diterpenoid which has been proved to show antimicrobial activity.

Antioxidant and antiinflammatory activities of Sideritis perfoliata subsp. perfoliata (Lamiaceae)

“…Plants of this genus are widely used in traditional medicine in Greece and Europe due to their antiinflammatory, antirheumatic, antiulcer, digestive and antimicrobial properties (Quer, 1962;Diaz et al, 1988) which are attributed to their phenolic and terpenoid content (Koleva et al, 2003;Aboutabl et al, 2002;Akcos et al, 1999;Pang et al, 1996;Alcaraz et al, 1989).…”

Volatile constituents and biological activities ofPycnostachys abyssinicaandPycnostachys eminiiextracts

“…The family Lamiaceae is generally known to be a rich source of diterpenoids of many structural types which possess antibacterial and antifungal properties (Diaz et al, 1988;Gonzalez et al, 1989;Cole et al, 1991;Cole, 1992;Batista et al, 1994;Kilic, 2006). Similarly, the antimicrobial activity of plant steroids has also been demonstrated in many studies (Tanaka et al, 1969;Subhisha & Subramoniam, 2005;Rojas et al, 2006 Accordingly, diterpenoids and steroids detected in P. abyssinica and P. eminii might be responsible for the inhibitory effect observed against the sensitive microorganisms.…”

Some Biological Compounds, Radical Scavenging Capacities and Antimicrobial Activities in the seeds of <i>Nepeta italica</i> L. and <i>Sideritis montana</i> L. subsp. <i>montana</i> from Turkey

“…A previous study reported that the Sideritis species could be used as natural antimicrobial and antioxidant agents in food preservation and human health (Sagdic et al, 2008). Several studies suggested that Nepeta and Sideritis species have antimicrobial and antifungal activities (Diaz et al, 1988;Ezer and Abbasog lu, 1996;Nostro et al, 2001;Basile et al, 2006). Kursat and Erecevit (2009) Hernandez-Perez and Rabal, 2002;Proestos et al, 2006).…”