Studies on tryptophan metabolism in protein-calorie malnutrition

Abbassy, A. S.; Zeitoun, Moustafa M.; Hassanein, E. A.; Abdel-Tawab, G.A.; Kholief, T. S.; El-Sewedy, S.W.

doi:10.1016/0035-9203(70)90208-7

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…17 Researchers have looked into nutritional treatments in both subclinical and illness phases of PEM. 73–75 High quality tryptophan food supplements can be useful 73 and anabolic support might produce better outcomes in acutely sick infants. 72 Children with PEM appear to possess an altered disposition in their utilization of medications, although some of the outcomes of their therapies remained inconclusive.…”

Section: Nutritional Status and Convalescence Outcomementioning

confidence: 99%

Article Commentary: Kynurenine Pathway Pathologies: Do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)

Blankfield¹

2013

Int J�Tryptophan�Res

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The definition of dual tryptophan pathways has increased the understanding of the mind-body, body-mind dichotomy. The serotonergic pathway highlights the primary (endogenous) psychiatric disorders. The up-regulation of the kynurenine pathway by physical illnesses can cause neuropathic and immunological disorders1 associated with secondary neuropsychiatric symptoms.Tryptophan and nicotinamide deficiencies fall within the protein energy malnutrition (PEM) spectrum. They can arise if the kynurenine pathway is stressed by primary or secondary inflammatory conditions and the consequent imbalance of available catabolic/anabolic substrates may adversely influence convalescent phase efficiency. The replacement of depleted or reduced NAD+ levels and other cofactors can perhaps improve the clinical management of these disorders.Chronic fatigue syndrome (CFS) and fibromyalgia (FM) appear to meet the criteria of a tryptophan-kynurenine pathway disorder with potential neuroimmunological sequelae. Aspects of some of the putative precipitating factors have been previously outlined.2,3 An analysis of the areas of metabolic dysfunction will focus on future directions for research and management.

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