Study of Adaptogenic Properties of the Drug Klim Pet Under Stress of Dogs in a Megalopolis

Lukoyanova, L. A.; Kriyachko, Oksana; Gaponova, Viktoriya; Anisimova, Kseniya; Shafiev, A.P.

doi:10.1096/fasebj.2021.35.s1.02469

Cited by 5 publications

(1 citation statement)

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“…Изменение морфологических показателей крови у крыс контрольной группы соответствовали таковым при реализации стрессовой реакции (2) и согласовывались с нашими результатами при модели- (3,4,7). Таким образом, можно рекомендовать профилактическое использование исследованной добавки Клим при прогнозировании стрессовой ситуации любого генеза (перегруппировка, холод, транспортировка).…”

Section: результаты и обсуждениеunclassified

Correction of post-stress disorders in rats in model experiments

Kryachko¹,

Lukoyanova²

2023

jour

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The development of drugs to correct post -stress reactions, manifested by profound changes in homeostasis, is relevant for both human and veterinary medicine. The purpose of our study is to study the possibility of using the Klim organomineral supplement for the correction of post-stress disorders in rats in model experiments.Wistar rats, four-month-old males weighing 350-400 grams, were used as the object of the study. For the study, animals were divided into 3 groups, intact, control and experimental were used to simulate stress reactions when exposed to low temperatures. Animals of the experimental group 21 days before the model experiments were given a daily Klim supplement with food .The use of the Klim organomineral supplement to leveling the negative effects on blood morphological parameters when modeling acute stress, which is confirmed by our studies in production. Thus, it is possible to recommend the prophylactic use of the studied additive Klim in predicting a stressful situation of any origin (regrouping, cold, transportation).

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Section: результаты и обсуждениеunclassified

Correction of post-stress disorders in rats in model experiments

Kryachko¹,

Lukoyanova²

2023

jour

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The effect of Klim feed additive on metabolic processes in cows after calving

Kryachko¹,

Lukoyanova²

2021

jour

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During pregnancy, calving and milking, the body of cows experiences stress, which leads to a decrease in productivity and disruption of metabolic processes, and as a result to significant economic losses of milk producers, as well as to premature culling of animals.The developers offer various feed additives that help limit the manifestation of stress, one of them is the organomineral Klim supplement, consisting of organic acids and mineral components, with the properties of a universal adaptogen.The study was carried out on cows of the Leningrad region livestock farm, and the effect of the Klim supplement on the general clinical condition of cows and metabolic processes by biochemical blood analysis was taken into account.According to the results of the study, it was revealed that the Klim feed additive we studied, developed for use in cattle, had a positive effect on the nature of metabolic processes in cows during the difficult period of late pregnancy and the early period after calving. The drug helped to reduce the excess content of under-oxidized metabolic products in the cows of experimental animals, leading to the development of acidosis and eventually ketosis. We also noted the normalization of protein metabolism. In addition, the exterior of the animals was improved. Against the background of the use of the Klim supplement, ruminants also adapted faster and easier to changes in the external environment.

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Hyaluronic acid as a means to correct entropion in animals

Guliaeva¹,

Gaponova²

2023

jour

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Entropion, or inversion of the edge of the eyelid, is a frequent multifactorial disease in which the ciliated edge of the eyelid is wrapped inside, which leads to permanent corneal trauma and eye irritation. Currently, subcutaneous fillers based on hyaluronic acid are used to correct entropion due to the fact that it does not have organ- and speciesspecificity and, therefore, carries a minimal risk of allergic reactions. The advantage of subcutaneous fillers based on HA is that the injection can be reversed with the development of complications with the help of drugs based on hyaluronidase. The assessment was carried out by the amount of periocular moistening, alopecia and/or hyperemia of the eyelids with manual rotation of the eyelids outward during the examination. All patients underwent a complete ophthalmological examination with a slit lamp and indirect ophthalmoscopy, a Schirmer test and intraocular pressure. The injection methods used included linear threading, a series of single-point injections, or a combination of them. The criteria for evaluating the effectiveness of the use of hyaluronic acid as a means for correcting entropion in animals were local reactions to skin filler, inflammatory processes in the eye area associated with a relapse of entropion, as well as the duration of the period before repeated administration of the drug. The technique of subcutaneous injection of the GC filler is a simple, reliable, effective, safe, prolonged procedure that requires a minimum amount of time, which allows you to immediately alleviate the patient's condition from mild to moderate severity as a result of entropion in cats and dogs. This procedure is especially preferable for age-related patients and patients with high anesthetic risk.

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Study of Adaptogenic Properties of the Drug Klim Pet Under Stress of Dogs in a Megalopolis

Cited by 5 publications

References 0 publications

Correction of post-stress disorders in rats in model experiments

Correction of post-stress disorders in rats in model experiments

The effect of Klim feed additive on metabolic processes in cows after calving

Hyaluronic acid as a means to correct entropion in animals

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