Study of brain and vascular plexus gangliosides in meningoencephalites of various etiology

Karpova, O B; Zinserling, Vsevolod; Аврова, Н. Ф.

doi:10.1016/0197-0186(92)90051-r

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Previously, we found that substances from destroyed brain cells first accumulate in the choroid plexus, and then are gradually excreted therefrom through the cerebro spinal fluid. Indeed, it has been demonstrated that in children with meningoencephalitis (postmortem studies), the level of gangliosides in the choroid plexus is higher than in the brain tissue [23]. Thus, if the level of gangliosides in the cerebrospinal fluid significantly increases during the destruction of neurons and other brain cells, then they could acti vate phagocytosis of apoptotic neurons by brain astrocytes, thus exerting a neuroprotective effect on the remaining viable brain neurons.…”

Section: Discussionmentioning

confidence: 99%

Phagocytic Activity of Rat Primary Astrocytes Is Regulated by Insulin and Ganglioside GM1

Соколова

Rychkova

Basova

et al. 2021

J Evol Biochem Phys

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A timely and efficient removal of apoptotic cells and their fragments is essential to maintain tissue homeostasis in normal and pathological conditions. Since the removal of apoptotic substrates is executed by the cells endowed with phagocytic activity, the issue of its regulation is of particular interest. In this work, we studied the effect of two biologically active substances, insulin and ganglioside GM1, on phagocytic activity of rat primary astrocytes. We showed that cell incubation with 1 µM insulin significantly decreased the phagocytic activity of astrocytes (58.5% vs. control), whereas the incubation with 10 µM GM1 caused an increase in phagocytic activity (133.4% vs. control). Preincubation of brain astrocytes with GM1 completely blocked the inhibitory effect of insulin. These results can be instrumental in developing novel therapeutic strategies for the treatment of neurodegenerative diseases accompanied by the emergence of apoptotic substrates.

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Section: Discussionmentioning

confidence: 99%

Phagocytic Activity of Rat Primary Astrocytes Is Regulated by Insulin and Ganglioside GM1

Соколова

Rychkova

Basova

et al. 2021

J Evol Biochem Phys

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Аврова

Захарова

et al. 2002

Neurochemical Research

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The metabolic effects of ganglioside GM1 were found to be quite different in brain synaptosomes and phagocytic cells. Incubation of rat brain cortex synaptosomes with GM1 was shown to decrease the production of reactive oxygen species induced by Fe2+-H2O2 system and measured by chemiluminometric method in the presence of luminol. Gangliosides GM1, GD1a, and GT1b significantly diminished the induced accumulation of lipid peroxidation product in brain synaptosomes, but protein kinase inhibitor (polymyxin B) abolished this effect. Incubation with antioxidants or GM1 significantly diminished the increase of 45Ca2+ influx and oxidative inactivation of Na+,K+-ATPase in brain synaptosomes exposed to glutamate, the effect of GM1 was concentration-dependent in the range 10(-11)-10(-8) M. But the incubation of human neutrophils and mouse peritoneal macrophages with 10(-11)-10(-10) M GM1, on the contrary, increased several times the luminol-dependent chemiluminescence response of these cells to activation by low concentrations of 12-myristate-13-acetate phorbol ester. The opposite effects of GM1 in the nerve endings and phagocytic cells seem to be protective in both cases as the inhibition of reactive oxygen species production in the nerve cells may enhance their viability in damaged brain, while the intensification of their production in phagocytic cells may promote the resistance of organism to infection.

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The protective effect of GD1a ganglioside and inhibitors of nitric oxide synthase after the application of bacterial lipopolysaccharide to PC12 cells

et al. 2012

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Study of brain and vascular plexus gangliosides in meningoencephalites of various etiology

Cited by 3 publications

References 9 publications

Phagocytic Activity of Rat Primary Astrocytes Is Regulated by Insulin and Ganglioside GM1

Phagocytic Activity of Rat Primary Astrocytes Is Regulated by Insulin and Ganglioside GM1

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The protective effect of GD1a ganglioside and inhibitors of nitric oxide synthase after the application of bacterial lipopolysaccharide to PC12 cells

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