Study of Breath Acetone in a Rat Mode of 126 Rats with Type 1 Diabetes

Wang, Zhennan; Sun, Meixiu; Zhao, Xiaoyan; Jiang, Chenchen; Li, Yingxin; Wang, Chuji

doi:10.4172/2155-9872.1000344

Cited by 4 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the correlation between blood glucose level and the detected acetone is controversial as discussed in the literature [64]: positive [65] negative [66,67], some arguing no correlation [68][69][70]. The core problem of BGL-detection based on exhaled breath analysis is that the acetone level is influenced by many factors such as insulin injection, type of diabetes, alcohol intake, exercise, food and beverage intake, etc.…”

Section: Exhaled Breath Analysismentioning

confidence: 99%

Commercial and Scientific Solutions for Blood Glucose Monitoring—A Review

Xue

Thalmayer

Zeising

et al. 2022

Sensors

View full text Add to dashboard Cite

Diabetes is a chronic and, according to the state of the art, an incurable disease. Therefore, to treat diabetes, regular blood glucose monitoring is crucial since it is mandatory to mitigate the risk and incidence of hyperglycemia and hypoglycemia. Nowadays, it is common to use blood glucose meters or continuous glucose monitoring via stinging the skin, which is classified as invasive monitoring. In recent decades, non-invasive monitoring has been regarded as a dominant research field. In this paper, electrochemical and electromagnetic non-invasive blood glucose monitoring approaches will be discussed. Thereby, scientific sensor systems are compared to commercial devices by validating the sensor principle and investigating their performance utilizing the Clarke error grid. Additionally, the opportunities to enhance the overall accuracy and stability of non-invasive glucose sensing and even predict blood glucose development to avoid hyperglycemia and hypoglycemia using post-processing and sensor fusion are presented. Overall, the scientific approaches show a comparable accuracy in the Clarke error grid to that of the commercial ones. However, they are in different stages of development and, therefore, need improvement regarding parameter optimization, temperature dependency, or testing with blood under real conditions. Moreover, the size of scientific sensing solutions must be further reduced for a wearable monitoring system.

show abstract

Section: Exhaled Breath Analysismentioning

confidence: 99%

Commercial and Scientific Solutions for Blood Glucose Monitoring—A Review

Xue

Thalmayer

Zeising

et al. 2022

Sensors

View full text Add to dashboard Cite

show abstract

“…The simultaneous single measurement of blood glucose and breath acetone in diabetes patients are reported in the literature [45,214,221,222]. A more comprehensive measurement involving continuous simultaneous acetone and glucose monitoring in order to observe the trends in both measurements are reported in [43,[215][216][217]219].…”

Section: Non-invasive Glucose Sensing Based On Breath Acetone Analysismentioning

confidence: 99%

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Shokrekhodaei

Quinones

2020

Sensors

156

109

View full text Add to dashboard Cite

Annual deaths in the U.S. attributed to diabetes are expected to increase from 280,210 in 2015 to 385,840 in 2030. The increase in the number of people affected by diabetes has made it one of the major public health challenges around the world. Better management of diabetes has the potential to decrease yearly medical costs and deaths associated with the disease. Non-invasive methods are in high demand to take the place of the traditional finger prick method as they can facilitate continuous glucose monitoring. Research groups have been trying for decades to develop functional commercial non-invasive glucose measurement devices. The challenges associated with non-invasive glucose monitoring are the many factors that contribute to inaccurate readings. We identify and address the experimental and physiological challenges and provide recommendations to pave the way for a systematic pathway to a solution. We have reviewed and categorized non-invasive glucose measurement methods based on: (1) the intrinsic properties of glucose, (2) blood/tissue properties and (3) breath acetone analysis. This approach highlights potential critical commonalities among the challenges that act as barriers to future progress. The focus here is on the pertinent physiological aspects, remaining challenges, recent advancements and the sensors that have reached acceptable clinical accuracy.

show abstract

“…Increasing interest has been expressed in the possibility of breath analysis as diagnostic and monitoring tools [5,6]. For instance, exhaled nitric oxide (NO) was demonstrated to be an indicator of asthma or airway inflammation [7,8], acetone was found to be more abundant in the breath of diabetics [9][10][11][12], exhaled ammonia level is significantly elevated in patients with renal diseases [13], and increased alkanes and formaldehyde concentration is present in the case of lung cancer and breast cancer [14]. For patients with asthma, chronic obstructive pulmonary disease (COPD), pneumonia or sleep apnea, the lungs cannot remove enough of the CO 2 produced by the body, and respiratory acidosis may occurs [15].…”

Section: Introductionmentioning

confidence: 99%

Near-infrared tunable diode laser absorption spectroscopy-based determination of carbon dioxide in human exhaled breath

Lou

Jing

Wang

et al. 2019

Biomed. Opt. Express

View full text Add to dashboard Cite

A spectroscopic detection system for the accurate monitoring of carbon dioxide (CO 2 ) in exhaled breath was realized by tunable diode laser absorption spectroscopy (TDLAS) in conjunction with a vertical-cavity surface-emitting laser (VCSEL) and a multipass cell with an effective optical path-length of 20 m. The VCSEL diode emitting light with an output power of 0.8 mW, covered the strong absorption line of CO 2 at 6330.82 cm −1 by drive-current tuning. The minimum detectable concentration of 0.769% for CO 2 detection was obtained, and a measurement precision of approximately 100 ppm was achieved with an integration time of 168 s. Real-time online measurements were carried out for the detection of CO 2 expirograms from healthy subjects, different concentrations were obtained in dead space and alveolar gas. The exhaled CO 2 increased significantly with the increasing physical activity, reaches its maximal value at the beginning of respiratory compensation and then decreased slightly until maximal exercise. The developed measurement system has a great potential to be applied in practice for the detection of pulmonary diseases associated with CO 2 retention.

show abstract

Study of Breath Acetone in a Rat Mode of 126 Rats with Type 1 Diabetes

Cited by 4 publications

References 22 publications

Commercial and Scientific Solutions for Blood Glucose Monitoring—A Review

Commercial and Scientific Solutions for Blood Glucose Monitoring—A Review

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Near-infrared tunable diode laser absorption spectroscopy-based determination of carbon dioxide in human exhaled breath

Contact Info

Product

Resources

About