Study of complement activation, C3 and interleukin-6 levels in burn patients and their role as prognostic markers

Modi, Syamal; Rashid, Mohd Harun Or; Malik, Abida; Shahid, Mohd

doi:10.4103/0255-0857.129793

Cited by 12 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Up regulation of IL-6 was observed at wound sites during skin wound healing in mice (Satoand Ohshima, 2000).Additionally, Sasaki et al (2011) suggested positive association between IL-6 and burninduced immune-inflammatory response during the burn healing process. Increased levels of IL-6 within hours of thermal trauma have been reported by Modi et al (2014).In addition, Guo et al (1990) reported increased serum levels of IL-6 over a 3-week interval with peak concentrations reached during the first week after injury in a population of burn patients.…”

Section: Discussionmentioning

confidence: 83%

Role of Inducible Nitric Oxide Synthase and Interleukin-6 Proteins Expression in Estimation of Skin Burn Age and Vitality: Immunohistochemical Study in Rat

El-Noor

Elgazzar

Alshenawy

2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

All rights reserved. Introduction ound examination is an essential issue in forensic practice. Determination of wound age and vitality is a classic but still popular and pivotal issue in forensic pathology to evaluate accurately its causal relationship to death (Kubo, 2014). Wound healing is a dynamic process consisting of three overlapping phases: the inflammatory phase; including coagulation and inflammation, the proliferative phase; consisting of angiogenesis, the formation of granulation tissue, and re-epithelialization, and lastly the maturation phase; involving matrix formation and tissue remodeling (Mendonça and Coutinho-Netto, 2009). There are many studies investigated determination of mechanically induced skin wounds by sharp or blunt objects using either animal experiments or samples from cadavers (Takamiya et al., 2002; Kondo, 2007; Kondo and Ishida, 2010). Despite burn injuries are considered a major cause of disability and death (Alsarhan et al., 2013); limited information is available on the determination of skin burn injury.

show abstract

Section: Discussionmentioning

confidence: 83%

Role of Inducible Nitric Oxide Synthase and Interleukin-6 Proteins Expression in Estimation of Skin Burn Age and Vitality: Immunohistochemical Study in Rat

El-Noor

Elgazzar

Alshenawy

2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

show abstract

“…In murine models of cecal ligation and puncture (CLP), C3 and C4 deficient mice are more likely to experience septic shock, and the absence of C3 is associated with increased mortality in sepsis [6]. Low C3 has also been associated with mortality in infected humans in a handful of small observational studies [26][27][28]. To our knowledge, this is the first study to report an association between low C4 levels and mortality during gram-negative bloodstream infection, and further studies are needed to validate this finding.…”

Section: Discussionmentioning

confidence: 99%

Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria

Eichenberger

Dagher

Ruffin

et al. 2020

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

The complement system is a vital component of the innate immune system, though its role in bacteremia is poorly understood. We present complement levels in Staphylococcus aureus bacteremia (SAB) and Gram-negative bacteremia (GNB) and describe observed associations of complement levels with clinical outcomes. Complement and cytokine levels were measured in serum samples from 20 hospitalized patients with SAB, 20 hospitalized patients with GNB, 10 non-infected hospitalized patients, and 10 community controls. C5a levels were significantly higher in patients with SAB as compared to patients with GNB. Low C4 and C3 levels were associated with septic shock and 30-day mortality in patients with GNB, and elevated C3 was associated with a desirable outcome defined as absence of (1) septic shock, (2) acute renal failure, and (3) death within 30 days of bacteremia. Low levels of C9 were associated with septic shock in patients with GNB but not SAB. Elevated IL-10 was associated with increased 30-day mortality in patients with SAB. Complement profiles differ in patients with SAB and those with GNB. Measurement of IL-10 in patients with SAB and of C4, C3, and C9 in patients with GNB may help to identify those at higher risk for poor outcomes.

show abstract

“…Complement activation was revealed to occur mainly via the AP evidenced by a massive drop of the hemolytic activity in the alternative pathway (AH50) in the first hours following trauma, while the hemolytic activity of the classical pathway (CH50) remained normal or even supranormal [ 99 ]. C3 plasma levels are inversely correlated with the burn severity and could be used as a prognostic marker [ 100 ]. However, in the course of 2 weeks after burn, AH50 and CH50 increase concomitant with the presence of complement proteins (e.g., C3 and C4).…”

Section: Burnmentioning

confidence: 99%

Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis

et al. 2021

View full text Add to dashboard Cite

Complement is one of the most ancient defense systems. It gets strongly activated immediately after acute injuries like trauma, burn, or sepsis and helps to initiate regeneration. However, uncontrolled complement activation contributes to disease progression instead of supporting healing. Such effects are perceptible not only at the site of injury but also systemically, leading to systemic activation of other intravascular cascade systems eventually causing dysfunction of several vital organs. Understanding the complement pathomechanism and its interplay with other systems is a strict requirement for exploring novel therapeutic intervention routes. Ex vivo models exploring the cross-talk with other systems are rather limited, which complicates the determination of the exact pathophysiological roles that complement has in trauma, burn, and sepsis. Literature reporting on these three conditions is often controversial regarding the importance, distribution, and temporal occurrence of complement activation products further hampering the deduction of defined pathophysiological pathways driven by complement. Nevertheless, many in vitro experiments and animal models have shown beneficial effects of complement inhibition at different levels of the cascade. In the future, not only inhibition but also a complement reconstitution therapy should be considered in prospective studies to expedite how meaningful complement-targeted interventions need to be tailored to prevent complement augmented multi-organ failure after trauma, burn, and sepsis.This review summarizes clinically relevant studies investigating the role of complement in the acute diseases trauma, burn, and sepsis with important implications for clinical translation.

show abstract

Study of complement activation, C3 and interleukin-6 levels in burn patients and their role as prognostic markers

Abstract: Complement activation, C3 and IL-6 levels correlated well with the severity of injury and development of infection in burn patients. These parameters can be used to predict the onset of infection, septicaemia and mortality in burn patients.

Cited by 12 publications

References 22 publications

Role of Inducible Nitric Oxide Synthase and Interleukin-6 Proteins Expression in Estimation of Skin Burn Age and Vitality: Immunohistochemical Study in Rat

Role of Inducible Nitric Oxide Synthase and Interleukin-6 Proteins Expression in Estimation of Skin Burn Age and Vitality: Immunohistochemical Study in Rat

Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria

Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis

Contact Info

Product

Resources

About