Study of effects of mifepristone on full-term pregnancies

Comparison of outpatient with inpatient mifepristone usage for cervical ripening: A randomised controlled trial

“…We found that women who underwent outpatient cervical ripening with mifepristone had the same rate of Bishop score improvement as women in the inpatient group at 24 h (1 (1–2) vs. 1 (1–2), P = 0.416) and 48 h (3 (2–4) vs. 3 (1–4), P = 0.527). This Bishop score improvement was the same as or slightly lower than that reported in other studies [25] , [26] , [27] , [30] , [31] , [32] , [33] , [34] , [35] , [36] .…”

“…The frequent use of these additional preinduction methods was due to the need to achieve a high degree of cervical ripening (8 points on the Bishop scale) in accordance with our local protocol. A similar frequency of additional preinduction methods was reported by Sharma et al (73.3 % of dinoprostone gel) [27] and Wing et al (67.0 % of misoprostol) [29] . Sujithra et al reported a lower frequency of dinoprostone gel use (32 %); however, in every fifth case, it was reused twice [35] .…”

“…The efficacy and safety of mifepristone for the preinduction/induction of labour have been confirmed in observational and randomised trials [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] .…”

The efficacy and influence factors analysis of Mifepristone combined with estrogen-progesterone in the treatment of incomplete abortion

“…Meanwhile, Mifepristone causes softening and dilatation of the human pregnant cervix, resulting in increased uterine activity, so that the intrauterine residues can be eliminated from the body. [ 14 , 15 ]…”

“…Meanwhile, Mifepristone causes softening and dilatation of the human pregnant cervix, resulting in increased uterine activity, so that the intrauterine residues can be eliminated from the body. [14,15] In estrogen-progesterone sequential therapy, estrogen attaches to the receptor and causes hyperplasia of the endometrial vasculature and proliferation of glands cells, which fixes the endometrium. Furthermore, estrogen improves the sensitivity of the uterine smooth muscle to oxytocin, which strengthens the contraction of the uterine smooth muscle and induces residual pregnancy tissue stripping from the uterine wall.…”