Study of Electrochemical Impedance of a Continuous Glucose Monitoring Sensor and its Correlation With Sensor Performance

Ghoreishizadeh, Sara S.; Zhang, Xiaotian; Sharma, Sanjiv; Georgiou, Pantelis

doi:10.1109/lsens.2017.2778248

Cited by 22 publications

(5 citation statements)

References 23 publications

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“…The authors have studied the electrochemical impedance and the sensitivity of commercially available CGM sensors (Medtronic Enlite sensors; working electrode area of 2 mm2) over the life-time of the sensors. The results presented in [10] show that the sensitivity is related to the double-layer capacitance and charge-transfer resistance, based on results acquired from a sensor that showed substantial sensitivity drop. Two data clusters are extracted that relate the sensor sensitivity to its impedance before and after the sensitivity drops by more than 50% (see Fig.…”

Section: A Sensor Calibrationmentioning

confidence: 89%

“…The correlation between sensor sensitivity and double layer capacitance: two data clusters are visible around the initial and reduced sensitivity of the sensor. Reprinted from [10] indication of the end of the life-time of the sensor. This feature can be embedded into the wearable device to check the health of the sensor and to implement real-time calibration based on impedance; eliminating the need for external gold references for sensor calibration.…”

Section: A Sensor Calibrationmentioning

confidence: 99%

See 1 more Smart Citation

Towards self-powered and autonomous wearable glucose sensor

Ghoreishizadeh

Moschou²,

McBay³

et al. 2018

2018 25th IEEE International Conference on Electronics, Circuits and Systems (ICECS)

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Blood glucose diagnostic systems are a worldwide success story. Nevertheless, all the painless solutions available are too expensive to be disposable. We aim to bridge this gap by developing a painless disposable diabetes diagnostic patch. Our envisaged device is fully integrated and autonomous: harvests the required energy from the environment and features sensor autocalibration in real-time. In this paper, we present the design and preliminary results of the different parts in the wearable patch: electrochemical glucose sensor developed on scalable PCB technology, biofuel cell based on glucose in the biofluid sample, and instrumentation electronics designed on a PCB with energy and data management blocks.

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Section: A Sensor Calibrationmentioning

confidence: 89%

Section: A Sensor Calibrationmentioning

confidence: 99%

Towards self-powered and autonomous wearable glucose sensor

Ghoreishizadeh

Moschou²,

McBay³

et al. 2018

2018 25th IEEE International Conference on Electronics, Circuits and Systems (ICECS)

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is also imperative to study the biofouling effects from the sample and how calibrations may be carried out conveniently. For instance, [93] demonstrated that there is a correlation between the occurrence of a fault in the glucose sensor with the sensor's double-layer capacitance. Such a correlation introduces the possibility for an in-situ faulty sensor detection or potentially sensor calibration, where sensor sensitivity may be predicted in situ through easily measurable sensor characteristics such as impedance.…”

Section: B1 Sensor Reusability and Calibrationmentioning

confidence: 99%

Electrochemical Sensors for Cortisol: A Review

Naeem,

Guldin,

Ghoreishizadeh

2024

IEEE Sensors J.

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Cortisol, also known as the "stress hormone", is secreted under the control of the hypothalamic-pituitary-adrenocortical (HPA) axis in response to psychobiological stress. Real-time and continuous monitoring of the cortisol levels throughout the day can provide the information necessary to identify any abnormalities in cortisol's circadian rhythm that may disrupt the several processes that cortisol is involved in in the body. This review presents a systematic search of the literature on electrochemical cortisol sensing techniques that allow real-time measurement of cortisol in human biofluids. Several structural and performance-related parameters of sensors are being discussed, including the sensor stack layers, limit of detection (LoD), dynamic range, sensitivity, selectivity, reusability, redox probe usage, and the electrochemical detection technique used. The sensors here are primarily categorized based on the type of bioreceptors used: antibodies, molecularly imprinted polymers (MIPs), and aptamers. According to this review, cortisol aptasensors and the MIP-based sensors present, in general, superior stability and sensitivity over immunosensors. They also promise reversible binding, albeit limited research exists on sensors deploying such bioreceptors. Additionally, notable advancements in the field and their impact on the development of point-of-care (PoC) and wearable devices are discussed.

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“…Redox-mediated glucose biosensor faced problems in maintaining mediator and enzyme near the electrode due to small and diffusive molecules [11].The third generation enzymatic electrochemical biosensors do not require mediator where electrons are directly transferred between enzymes and electrodes [11]. Recent advances in nanostructures and nanotubes such as graphene and carbon nanotubes are promising for the development of nano electrodes and enzymatic electrochemical nano sensors used to develop convenient blood glucose monitors [12][13][14]. Enzymatic electrochemical biosensors are characterized by shorter stability; relatively higher fabrication costs, complicated modification and limitations associated with the nature of enzymes such as irreversibility, and signal drift [6,15,16].…”

Section: Invasive Blood Glucose Monitoring Techniques 21enzymatic Electrochemical Sensingmentioning

confidence: 99%

Blood glucose monitoring techniques: recent advances, challenges and future perspectives

Gamessa¹,

Suman²,

Tadesse³

2018

IJATEE

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Blood glucose monitor is a fundamental tool to maintain and control blood glucose levels for routine management of diabetes and complications associated with it. There have been continuous scientific advances and achievements in biosensors for the development of comprehensive glucose monitoring systems since last few decades. Portable, accurate, and reliable glucose monitoring devices with advanced features have been developed in recent years. However, invasive glucose monitors remained the most dominant devices on the market. Commercialization of clinically accurate and dependable non-invasive blood glucose monitoring devices still require rigorous works and further studies in sensor technologies. The aim of this article is to bring current updates and recent progress in electrochemical glucose sensing and non-invasive glucose monitoring techniques along with their merits and limitations. We present their key challenges and address future prospects of non-invasive glucose monitoring.

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Study of Electrochemical Impedance of a Continuous Glucose Monitoring Sensor and its Correlation With Sensor Performance

Cited by 22 publications

References 23 publications

Towards self-powered and autonomous wearable glucose sensor

Towards self-powered and autonomous wearable glucose sensor

Electrochemical Sensors for Cortisol: A Review

Blood glucose monitoring techniques: recent advances, challenges and future perspectives

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