Study of Endometrial Pathology in Abnormal Uterine Bleeding

Abstract

There is an age specific association of endometrial lesions. In perimenopausal women AUB is most commonly dysfunctional in origin and in reproductive age group, one should first rule out complications of pregnancy. The incidence of disordered proliferative pattern was significantly high in this study, suggesting an early presentation of these patients.

Histopathological pattern of endometrium in abnormal uterine bleeding of perimenopausal women

“…It is thought to be due to anatomic vascular variations or local abnormal defective haemostatic mechanisms. 12 In this study, endometrial carcinoma was found in 2 (1.11%) cases, which is almost similar to that reported by Khan S et al and Jairajpuri ZS et al 17 In the present study, endometrial carcinoma was found in ˃ 50 years of age group. A study done by Dangal et al in Nepal documented a lower incidence of endometrial cancer in Nepalese woman attributing it to the practice of early childbearing and multiparty.…”

“…In our study, simple hyperplasia was predominant which was similar to the study of Doraiswami S et al who observed 68% incidence of endometrial hyperplasia in 40-49 years of age group. 12 Endometrial hyperplasia is commonly seen in perimenopausal age group due to failure of ovulation. Persistent unriped follicles expose the endometrium to excessive and prolonged estrogenic action.…”

“…In other studies its incidence varies from 1.1%-7%. 12,[16][17][18][19] The exact cause of bleeding in atrophic endometrium is not known. It is thought to be due to anatomic vascular variations or local abnormal defective haemostatic mechanisms.…”

Distribution of causes of abnormal uterine bleeding using new FIGO classification system-PALM COEIN: a rural tertiary hospital based study

“…Similarly, study done by Doraiswamy et al also showed that polyps accounted for 11.2% cases of AUB. 13 The histopathology of endometrium showed proliferative phase which indicates that their growth is estrogen regulated.…”

A Study on Histopathological Patterns of Endometrium in Different Types of Abnormal Uterine Bleeding Among Peri And Postmenopausal Women

“…Similar to other studies, it is more common in the 41-50 age group. 15,[18][19] Diagnosing the patients at the earliest stage of this spectrum will be of definitive help to the practicing gynaecologists to prevent the disease progression.…”