Study of Exchange Transfusion by Reconstituted Blood in Hemolytic Disease of Fetus & New Born

Abstract

Introduction:In newborns with hemolytic disease of fetus and newborn, exchange transfusion is one of the treatments. The main objective of this study was to review and establish the practice of exchange transfusion with reconstituted blood in neonates and to observe fall of bilirubin and also rise in hemoglobin and its comparison with related studies. Material and methods:Total 31 neonates with hemolytic disease of fetus and newborn were included in this study and exchange transfusion was carried out to treat hyperbilirubinemia. Exchange transfusion with O Rh negative cells suspended in AB plasma were done for neonates having Rh hemolytic disease of fetus and newborn and O Rh positive cells suspended in AB plasma were used for exchange transfusion to ABO hemolytic disease of fetus and newborn. The pre and post exchange transfusion blood samples were tested for serum bilirubin and hemoglobin.Result: Out of the 31 cases, 20 were of Rhesus (Rh) hemolytic disease of fetus and newborn, while ABO and other blood groups constituted 08 and 03 hemolytic disease of fetus and newborn cases respectively. The average post-exchange fall in serum indirect bilirubin was (53.47%) and average rise in hemoglobin level was 3.06 gm/dl in all 31 cases. Conclusion:The reconstituted blood is immunologically much safer and better than whole blood for purpose of exchange transfusion in hemolytic disease of fetus and newborn because of its superiority in minimizing transfusion reactions and in achieving all the therapeutic effects of exchange transfusion in better way.