Study of Malignant Lymphoma in the Parotid Gland Region

Nagata, Motoki; Kumazawa, Hirobumi; Iwai, Hiroshi; Monotani, Akiyo; Shiraishi, Shugo; Yamashita, Toshio

doi:10.3950/jibiinkoka.99.918

Cited by 14 publications

(12 citation statements)

References 16 publications

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“…9 It is believed that the differentiation of malignant lymphoma originating in the parotid gland from other tumors (including benign tumors) is difficult; however, some authors as per the literature have reported that malignant lymphomas showed tumor homogeneity surrounded by well-defined margins and were rarely associated with necrosis. 10 So as per the observations of the present case, it is indicated that it is necessary to consider the possibility of malignant lymphoma even when the lesion is rapidly increasing in size and exhibits necrosis or an infiltrative tendency in the imaging presentations, strongly suggesting epithelial tumors. Malignant lymphoma originating in the parotid gland is histologically described as low-grade NHL that frequently belongs to the B-cell type and rarely relapses into other sites.…”

Section: Discussionsupporting

confidence: 65%

“…The MALT lymphoma is usually associated with chronic inflammatory process, which is either because of an immune process or infection, such as myoepithelial sialadenitis and Sjögren′s syndrome. 10 Schusterman et al 5 noticed a progressive increase in the incidence of salivary gland lymphomas during the last several decades. This may result from a combination of factors: (1) referral pattern, (2) increased lifespan of individual, and (3) use of sophisticated molecular techniques.…”

Section: Discussionmentioning

confidence: 99%

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Primary Non-Hodgkin's Lymphoma involving Parotid Gland: A Rare Entity

Vaidya¹,

Natrajan²,

Kadam³

2017

Journal of Contemporary Dentistry

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Non-Hodgkin's lymphomas constitute 25 to 40% of all lymphomas. The gastrointestinal tract is the most common site followed by the head and neck area. Salivary gland involvement is a very rare entity and is involved in 0.5 to 5% of all cases. Among all the major salivary glands, the parotid gland is commonly involved followed by the submandibular glands. Misdiagnosis often leads to unnecessary diagnostic procedures, which leads to delay in initiation of appropriate treatment. It is often difficult to diagnose the distinction between lymphoma developing primarily in the parotid gland tissue and in the intraparotid lymph nodes. As per the reports, primary tumors of the parotid gland show no characteristic features on diagnostic imaging, reflecting none of their histological findings. We represent a case of a 61-year-old female who presented with painless, gradually increasing mass in the right parotid region. Imaging studies were suggestive of an infiltrative mass lesion involving right the parotid gland. The patient underwent superficial parotidectomy along with the excision of the part of the deep lobe posterior to submandibular gland with facial nerve preservation. Histopathology of the resected specimen shows infiltrates of lymphocytes into the glandular parenchyma destroying its normal lobular organization and disrupting the normal glandular architecture.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Primary Non-Hodgkin's Lymphoma involving Parotid Gland: A Rare Entity

Vaidya¹,

Natrajan²,

Kadam³

2017

Journal of Contemporary Dentistry

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“…3 In general, malignant lymphoma originating the submandibular gland is histologically nonHodgkin's lymphoma, frequently belonging to the BCell type. 4,5,[16][17][18] Malignant lymphomas seen with AIDS are typically of a high grade and extranodal, often in the brain. They are very aggressive and respond poorly to therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, among lymphomas, non-Hodgkin's lymphoma is more common in submandibular gland, frequently B-cell type. [5][6][7] Treatment of primary lymphoma of submandibular gland includes submandibulectomy, radiotherapy and/or chemotherapy depending upon the grade of tumor, clearance of margin and associated lymphadenopathy and pre-op confirmed diagnosis of lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Diffuse large B cell lymphoma of submandibular gland in a seropositive case – a rare presentation

Binayke

Deshpande

2017

Int J Res Med Sci

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Lymphomas account for 2%-5% of salivary gland neoplasms. The parotid gland is the most commonly involved, constituting 70% of the cases, followed by submandibular gland (25%), sublingual and minor salivary glands (<10%). In present study a 56 years old seropositive male presented with a submandibular gland swelling of 2 months duration; along with multiple cervical lymphadenopathy. Grossly a single, well encapsulated, grayish-white tissue measuring 3x2.5x2 cms was received. It was solid, grayish-white on cut section. Histology revealed features of diffuse large B cell lymphoma with myoepithelial sialadenitis. Immunohistochemistry showed positivity for LCA & CD20, thus confirming the histopathological diagnosis. Primary malignant lymphoma of salivary glands is uncommon. Inspite of malignant lymphoma being the second most common AIDS-associated neoplasm, it’s occurrence in submandibular gland is extremely rare.

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“…It is difficult to differentiate between benign conditions from malignant tumours and therefore most patients are subjected to varied surgical procedures before a definitive diagnosis has been made. The head and neck region is the most common site where malignant lymphomas occur, but malignant lymphoma of the parotid gland is relatively rare [5]. Generally, surgeons do not anticipate primary Non Hodgkin's Lymphoma (NHL) in the salivary glands pre-operatively and pathologists too find it difficult to give a definitive and diagnostic report based on either frozen section or fine needle aspiration biopsy (FNAB) [6].…”

Section: Introductionmentioning

confidence: 99%

A Case of Primary Aggressive Non Hodgkin’s Lymphoma of Parotid Gland

Singh¹

2015

JOENTR

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Introduction: Primary parotid Non Hodgkin lymphoma is rare and is generally overlooked in differential diagnosis. A high index of suspicion is therefore warranted for the diagnosis. In the present case report, we describe a case of high grade diffuse large B cell Non-Hodgkin's lymphoma of the parotid gland.Case presentation: A 24 Years old Male presented with a painless mass over the Left parotid region. Imaging studies were suggestive of an infiltrative mass lesion in left parotid along with lytic lesions in vertebral bodies of dorsolumbar spine. The patient underwent total parotidectomy of left Parotid gland with facial nerve preservation. Histopathology of the resected specimen was consistent with primary diffuse large B cell lymphoma of the parotid gland. Conclusion:Lymphomas arising from the parotid gland are an uncommon entity, said to account for only 0.6-5% of tumors or tumor-like lesions of the parotid, and are therefore commonly overlooked. This misdiagnosis often leads to unnecessary diagnostic procedures, delaying the initiation of proper treatment.

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Study of Malignant Lymphoma in the Parotid Gland Region

Cited by 14 publications

References 16 publications

Primary Non-Hodgkin's Lymphoma involving Parotid Gland: A Rare Entity

Primary Non-Hodgkin's Lymphoma involving Parotid Gland: A Rare Entity

Diffuse large B cell lymphoma of submandibular gland in a seropositive case – a rare presentation

A Case of Primary Aggressive Non Hodgkin’s Lymphoma of Parotid Gland

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