Study of Nucleated Red Blood Cell Counts in Asphyxiated Newborns and the Fetal Outcome

Colaco,

doi:10.14740/ijcp169w

Cited by 5 publications

(10 citation statements)

References 10 publications

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“…The Apgar scores and the NRBC count were found to be inversely proportional. Similar observations were done by colacoa et al and Mohanty et al 16,17 …”

Section: Discussionsupporting

confidence: 89%

Study of cord blood nucleated RBC’s as a marker for fetal asphyxia

Ganta

Kulkarni

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Perinatal asphyxia is a serious problem globally and is a common cause of neonatal mortality and long term morbidity. Various Parameters are being used as predictors for birth asphyxia but the correlation between clinical presentation and the biochemical results has been unsatisfactory. NRBC count of the cord blood is reported in literature as a possible marker of perinatal asphyxia. In-utero hypoxic episode may induce a haemopoetic response of exaggerated erythropoiesis leading to the presence of nucleated RBC's in fetal circulation. The aim of this study was to investigate whether NRBC count of the cord blood can be a useful parameter to determine perinatal asphyxia.Methods: This prospective case control study was conducted in Chinmaya Mission hospital, Bangalore, India between July 2015 to June 2016.we have studied the NRBC counts from the cord blood of 50 neonates with perinatal asphyxia and 50 healthy neonates, thus comparing the results.Results: The mean NRBC /100 WBC for cases with birth asphyxia was 11.6 and that of the control group was 5.6. NRBC count was found to be significantly higher in neonates with low Apgar scores. There was correlation between the Apgar scores at 1st and at 5 minutes, the degree of Hypoxic Ischemic Encephalopathy and the NRBC counts.Conclusions: Therefore NRBC counts of the cord blood can be used as an effective tool to confirm perinatal asphyxia. It is a simple, quick, accurate and clinically effective test to diagnose and initiate treatment to prevent long term sequel of perinatal asphyxia.

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“…The Apgar scores and the NRBC count were found to be inversely proportional. Similar observations were done by colacoa et al and Mohanty et al 16,17 …”

Section: Discussionsupporting

confidence: 89%

Study of cord blood nucleated RBC’s as a marker for fetal asphyxia

Ganta

Kulkarni

2017

Int J Reprod Contracept Obstet Gynecol

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“…The positive and negative predictive values were 90.91% and 64.29% respectively (Table 6). [11][12][13][14] In the present study, attempt has been made to evaluate the relation of cord blood NRBC Count in predicting birth asphyxia and its immediate outcome.…”

Section: Resultsmentioning

confidence: 99%

“…The similar observations were also noted in previous studies. [11][12][13][14][15][16][17] We also evaluated the relation between patient outcome, Cord blood pH and NRBC Count. The mean cord blood pH was low in cases having unfavorable immediate and final outcome whereas mean NRBC count was on higher side in these cases.…”

Section: Resultsmentioning

confidence: 99%

Correlation of nucleated red blood cells with severity of birth asphyxia and its immediate outcome in term newborns

Meena

Gunawat

Suman

2016

Int J Contemp Pediatr

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“…The study of Sylvia et al observed that mean NRBC level in cases and control groups was 17.43±19.86/100 WBCs and 2.97±4.79/100 WBCs respectively. 13 Taking these values as reference, the minimum required sample size with 90% power of study and 5% level of significance was found to be 21 patients in each study group with using below mentioned formula.…”

Section: Sample Sizementioning

confidence: 99%

Cord blood and peripheral nucleated red blood cells levels in term asphyxiated and non-asphyxiated new borns and neonatal outcome: a comparative study

Chauhan

Jaipal²,

Bisht

et al. 2021

Int J Contemp Pediatr

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Background: Perinatal asphyxia can cause severe hypoxic-ischemic damages in the organs and causes severe long-term consequences. It has recently been suggested that the increase in NRBC count in the umbilical vein of newborns can be considered a sign of birth asphyxia. The aim of the study was to evaluate the role of cord blood nucleated RBC count as a marker for presence and severity of birth asphyxia.Methods: This prospective observational comparative study was conducted among 30 asphyxiated (case) and 30 non-asphyxiated newborns (control) in Swami Dayanand Hospital. Number of nucleated red blood cells in cord blood and peripheral blood were counted per 100 leukocytes in smears in cases and control. Maternal parameters and neonate characteristics were recorded in a proforma.Results: NRBC count increased in cord blood during the first few hours of life in perinatal asphyxia (10.79±9.58) as compared with the healthy control subjects (4.03±2.87, p=0.002). Significant positive correlation of C-NRBC and P-NRBC with NICU stay (r=0.921, p<0.0001 and r=0.698, p<0.0001 respectively). Nucleated RBC count more than 18 can be used as predictor of abnormal neurological outcome with sensitivity 100% and specificity of 93.1%. The cord blood NRBC >3/100 WBC has sensitivity of 92% and specificity of 77.8% in predicting birth asphyxia.Conclusions: Nucleated RBC count can be used as surrogate marker for birth asphyxia. It has significant positive correlation with severity of hypoxic ischemic encephalopathy, duration of NICU stay and duration of O2 requirement.

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Study of Nucleated Red Blood Cell Counts in Asphyxiated Newborns and the Fetal Outcome

Abstract: Background: The aim of the study was to find the values of nucleated red blood cells (NRBCs) in normal and asphyxiated babies and their correlation with simple clinical parameter and immediate outcome of such babies.

Cited by 5 publications

References 10 publications

Study of cord blood nucleated RBC’s as a marker for fetal asphyxia

Study of cord blood nucleated RBC’s as a marker for fetal asphyxia

Correlation of nucleated red blood cells with severity of birth asphyxia and its immediate outcome in term newborns

Cord blood and peripheral nucleated red blood cells levels in term asphyxiated and non-asphyxiated new borns and neonatal outcome: a comparative study

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