Study of serum LDH and GGT levels in carcinoma breast

Abstract

Background: Breast cancer is the second most common cancer in women next only to cervical cancer. Multiple factors are associated with an increased risk of developing breast cancer. For the early detection of carcinoma of breast, a number of biochemical markers have been studied to evaluate the malignancy. Aim: To analyse serum Lactate Dehydrogenase, Gamma Glutamyl Transpeptidase, liver enzymes (SGOT, SGPT, & ALP) and total proteins in diagnosis of carcinoma breast patients and compared with controls. And evaluate the relationship of serum LDH, GGT levels with ALP of carcinoma breast patients of post-menopausal age group. Material & Methods:The serum biochemical markers were estimated in 60(30-premenopausal women, 30-post menopausal women) clinically and histopathological confirmed patients with carcinoma breast and 40 number of healthy age-matched individuals served as control. Lactate dehydrogenase (LDH) Serum Gamma Glutamyl Transpeptidase (GGT), were analysed and estimated. Statistics: Data was analysed with student's paired 't'-test was determined. Results: The mean serum LDH, GGT, and ALP activities in patients with carcinoma breast were significantly (p<0.0001) increased as compared to controls, and a steady increase was observed in their levels from premenopausal to post-menopausal women. Conclusion: In this study, it is to suggest that the estimation of LDH, GGT, and ALP can be used as routine screening tests in all suspected carcinoma breast patients and for general population and can detect metastasis.

Study of Efficacy of Serum Lactate Dehydrogenase, Gamma Glutamyl Transpeptidase and Alkaline Phosphatase Levels as Prognostic and Diagnostic Markers in Breast Cancer

“…7). Present study findings are in accordance with the study conducted by Basnyat AS et al 9 Guddanti Rajeswari et al 10 , in their study, observed serum LDH is significantly increased in Ca breast patients when compared to controls. In the study of Aditi Agarwal et al .…”

“…Present study findings are in accordance with the study Basnyat AS et al 9 , Guddanti Rajeswari et al 10 , Jarari et al 16 Choudhari et al 14 andChandrakanth et al 17-----in their study observed serum GGT levels are significantly increased in Ca breast patients when compared to controls and also observed the further significantly increased levels of GGT (P-value <0.0001) in different stages of Ca breast cases compared to control subjects. In contrast, to present study Guddanti Rajeswari et al 10 , in their study, there is a negative correlation (r-value=-0.2105) of serum GGT with ALP levels in the post-menopausal group of breast cancer patients. In the present study, an increase in serum GGT activity is due to the rapid turnover of malignant cells, which release the enzymes into the bloodstream.…”

“…Guddanti Rajeswari et.al. 10 , Chandrakanth KH et al 11 , Swathi s.et al 13 , and prabhasheela et al 15 have found in their study, significantly increased serum ALP levels in breast cancer patients compared to controls. (Table 1) When all four stages were individually compared with control, we found that the alkaline phosphatase level was gradually increased with advancing stages.…”

Using of lactate dehydrogenase and Gamma glutamyl transpeptidase as routine screening test among patients with breast cancer

“…Our result also supported by some study mentions that level of LDHA is elevated in many malignant tumors and is associated with tumor proliferation and malignant growth, with potential implications for tumor diagnosis and therapy and The high activities of LDH in cancer cells may be due to the process of high cell proliferation, migration, or invasion than normal cells [20]. Our study also study revealed, Gamma glutamyl transpeptidase (GGT) were significantly increased only at grade III (p value 0.022) .These observations were in agreement with the studies of Fentiman, et al [21] and McElroy et al [22]. Other study conducted by Basnyat et al, find that LDH and GGT showed steady and progressive increase in the activities of these enzymes from stage I-IV.…”