Study of the etiopathogenesis and differential diagnosis of oral vascular lesions by immunoexpression of <scp>GLUT</scp>‐1 and <scp>HIF</scp>‐1α

Oliveira, Denise Hélen Imaculada Pereira De; Silveira, Éricka Janine Dantas da; Medeiros, Ana Miryam Costa de; Alves, Pollianna Muniz; Queiroz, Lélia Maria Guedes

doi:10.1111/jop.12092

Cited by 16 publications

(12 citation statements)

References 27 publications

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“…Erythrocytes served as positive internal controls. 8,9 Digital Analysis After immunohistochemistry for GLUT-1, slides of AM, AC, and TG were scanned into high-resolution images using the Aperio Scanscope CS Slide Scanner and digitally scored, as described previously. 10 Digital images were analyzed with Pixel Count V9 algorithm (Aperio Technologies Inc, Vista, CA).…”

Section: Methodsmentioning

confidence: 99%

Immunohistochemical Expression of GLUT-1 and HIF-1α in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma

et al. 2016

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Hypoxia-inducible factor-1α (HIF-1α) promotes proteins that enable cell survival during hypoxia, such as glucose transporter 1 (GLUT-1). Their coexpression has been associated with aggressiveness in malignancies and has not been studied in odontogenic tumors. Immunohistochemical expression of HIF-1α and GLUT-1 was analyzed in 13 tooth germs (TGs), 55 ameloblastomas (AMs), and 3 ameloblastic carcinomas (ACs). HIF-1α was negative in all TGs, and just 1 case of AM and 1 of AC had nuclear positivity. GLUT-1 expressed in ameloblastic cells of all TGs, AMs, and ACs, with an increasing intensity, respectively, and was significantly higher in solid AM than in unicystic AM (P = .041). Absence of nuclear HIF-1α in TGs and most AMs suggest that GLUT-1 may be induced by alternative pathways to hypoxia. However, in ACs, HIF-1α may be activated; however, to confirm this, additional cases are needed. GLUT-1 overexpression could be related to aggressiveness in AMs and ACs and must represent a normal metabolite in TGs.

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Section: Methodsmentioning

confidence: 99%

Immunohistochemical Expression of GLUT-1 and HIF-1α in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma

et al. 2016

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“…Unfortunately, information from the literature relating to the frequency of oral benign mucosal tumors is uncommon. Studies relating to benign tumors of the oral mucosa have been published in the literature, focusing on clinico-pathologic correlations of lipoma variants ( 2 - 5 ), salivary gland tumors ( 6 - 9 ), hemangiomas ( 10 - 12 ), neural ( 13 - 14 ) and other soft tissue mucosal tumors ( 15 - 21 ). Most of these do not relate directly to the clinical appearance and rate of ulceration of the tumors but rather, describe oral mucosal benign tumors as swellings or raised lesions.…”

Section: Introductionmentioning

confidence: 99%

The clinical characteristics of benign oral mucosal tumors

Allon¹,

Kaplan²,

Gal³

et al. 2014

Med Oral

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Objectives: To investigate the clinical characteristics and pre-biopsy provisional diagnoses of benign oral mucosal tumors. Material and Methods: A 10- year retrospective analysis of all benign tumors of the oral mucosa, from a university- affiliated oral and maxillofacial surgery department. Results: 146 benign tumors were included. The mean age was 49.6 years, with an approximately equal gender distribution. The most prevalent tumor types were lipomatous tumors (27.4%), vascular (23.3%), and salivary gland tumors (16.5%). Tongue, labial and buccal mucosa were the most frequently involved sites. The vast majority (98.6%) presented as non-ulcerated masses. Only 2 (1.4%) presented as ulcerated masses. The clinical provisional diagnosis correctly classified lesions as non-malignant in 93.3%. In only 9 (6.7%) suspicion of malignancy was included in the provisional diagnosis. However, benign neoplasia was unsuspected in 42.1% of tumors. These cases were clinically classified as reactive. Conclusions: Benign tumors were most likely to be clinically correctly classified as non-malignant, but even in the setting of experienced oral surgeons, neoplasia was unsuspected in more than 40% of cases. This data strongly supports the need to biopsy every oral mucosal mass, since inaccurate clinical evaluation of the lesion’s biological nature was a frequent event. Key words:Malignant, benign, reactive, ulcerated mass, non-ulcerated mass, clinical diagnosis.

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“…Different response to therapy of fingernail vs. toenail lesions and of nail bed vs. lateral nail fold location may be due to different expression of tissue markers, which we will possibly evaluate in further studies, using biopsy and immunohistochemistry. 5 Looking at propranolol efficacy according to PG aetiology, the effectiveness of the drug seem high in frictional PGs and in drug-induced PGs of the fingers, while it seems poor in druginduced PGs of the toes and in PGs due to nail ingrown.…”

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confidence: 99%

Topical propranolol 1% cream for pyogenic granulomas of the nail: open‐label study in 10 patients

Piraccini

Alessandrini

Dika

et al. 2015

Acad Dermatol Venereol

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Study of the etiopathogenesis and differential diagnosis of oral vascular lesions by immunoexpression of GLUT‐1 and HIF‐1α

Cited by 16 publications

References 27 publications

Immunohistochemical Expression of GLUT-1 and HIF-1α in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma

Immunohistochemical Expression of GLUT-1 and HIF-1α in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma

The clinical characteristics of benign oral mucosal tumors

Topical propranolol 1% cream for pyogenic granulomas of the nail: open‐label study in 10 patients

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