Study of the formation of biodegradable polycaprolactone particles using solvent evaporation method

Das, Pranjal Pratim; Huda, Muhsina K.; Saikia, Prakash J.; Baruah, Sanjib

doi:10.1080/10601325.2018.1547112

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…The microparticles were prepared using the oil-in-water solvent evaporation method with some modifications. − It has been reported that a change in the concentration of the emulsifier (PVA) can affect the size of the microparticles. , To prepare microparticles in the desired range of 40–70 μm, the concentration of PVA in the mixture must first be optimized. For this purpose, 100 mL of PVA solutions in MQ water at different concentrations (2.5, 3.5, 4, and 5 w/v %) was prepared.…”

Section: Methodsmentioning

confidence: 99%

Screening the Degradation of Polymer Microparticles on a Chip

et al. 2022

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Enzymatic degradation of polymers has advantages over standard degradation methods, such as soil burial and weathering, which are time-consuming and cannot provide time-resolved observations. We have developed a microfluidic device to study the degradation of single microparticles. The enzymatic degradation of poly (1,4-butylene adipate-co-terephthalate) (PBAT) microparticles was studied using Novozym 51032 cutinase. PBAT microparticles were prepared via an oil-in-water emulsion solvent removal method, and their morphology and chemical composition were characterized. Then, microparticles with varying diameters of 30−60 μm were loaded into the microfluidic chip. Enzyme solutions at different concentrations were introduced to the device, and changes in the size and transparency of PBAT microparticles were observed over time. The physicochemical properties of degraded products were analyzed by FT-IR, NMR, mass spectrometry, and differential scanning calorimetry. The degradation process was also performed in bulk, and the results were compared to those of the microfluidic method. Our analysis confirms that the degradation process in both bulk and microfluidic methods was similar. In both cases, degradation takes place on aliphatic and soft segments of PBAT. Our findings serve as a proof of concept for a microfluidic method for easy and time-resolved degradation analysis, with degradation results comparable to those of conventional bulk methods.

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