Study of the synergistic effects of all-transretinoic acid and C-phycocyanin on the growth and apoptosis of A549 cells

Li, Bing; Gao, Mei‐Hua; Lv, Cong-Yi; Yang, Peng; Yin, Qi-Feng

doi:10.1097/cej.0000000000000157

Cited by 18 publications

(14 citation statements)

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“…Non-small cell lung cancer, an extremely aggressive form of cancer with few effective therapeutic options, has attracted that attention of many investigators. Previous studies have suggested that phycocyanin exerts an inhibitory effect on A549 cells, a type of NSCLC cell line [ 21 , 22 , 23 ]. In this study, we demonstrated that phycocyanin inhibits the growth of H1299, H460, and LTEP-A2 NSCLC cell lines.…”

Section: Discussionmentioning

confidence: 99%

“…The inhibiting effect of phycocyanin on NSCLC has been reported in several studies. Li et al revealed that phycocyanin could inhibit the growth of NSCLC A549 cells in vivo and in vitro, which also has a synergistic anti-tumor effect with all-trans retinoic acid [ 21 , 22 ]. Bingula et al reported that phycocyanin and betaine have a synergistic inhibiting effect on the viability of A549 cells [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells

Hao

Yan

et al. 2018

Marine Drugs

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Phycocyanin, a type of functional food colorant, is shown to have a potent anti-cancer property. Non-small cell lung cancer (NSCLC) is one of the most aggressive form of cancers with few effective therapeutic options. Previous studies have demonstrated that phycocyanin exerts a growth inhibitory effect on NSCLC A549 cells. However, its biological function and underlying regulatory mechanism on other cells still remain unknown. Here, we investigated the in vitro function of phycocyanin on three typical NSCLC cell lines, NCI-H1299, NCI-H460, and LTEP-A2, for the first time. The results showed that phycocyanin could significantly induce apoptosis, cell cycle arrest, as well as suppress cell migration, proliferation, and the colony formation ability of NSCLC cells through regulating multiple key genes. Strikingly, phycocyanin was discovered to affect the cell phenotype through regulating the NF-κB signaling of NSCLC cells. Our findings demonstrated the anti-neoplastic function of phycocyanin and provided valuable information for the regulation of phycocyanin in NSCLC cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells

Hao

Yan

et al. 2018

Marine Drugs

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“…ATRA is often used to treat skin diseases and can also induce tumor cell differentiation and apoptosis. Li et al [ 90 , 91 ] investigated the in vitro and in vivo antitumor effect of the combination of C-PC and ATRA on A549 lung cancer cells. Their results showed that such a combination is better than that of single drug treatment, the dosage of ATRA is greatly reduced, and there were no obvious toxic side effects.…”

Section: Application Of C-pc In Tumormentioning

confidence: 99%

Medical Application of Spirulina platensis Derived C‐Phycocyanin

Liu

Huang

Zhang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

147

119

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Along with the development of marine biological pharmaceutical research, high-effective and low-toxic drugs and functional foods isolated from marine organisms have become a new field of pharmacy and bromatology. The pharmacological actions, such as anti-inflammation, antioxidation, antitumor, immunological enhancement, and hepatorenal protection of C-phycocyanin (C-PC) from Spirulina platensis, have been reported, and C-PC has important value of development and utilization either as drug or as functional food. There are many researches about the various pharmacological actions and mechanisms of C-PC, but related reports are only to some extent integrated deeply and accurately enough, which put some limitations to the further application of C-PC in medicine. Particularly, with the improvement of living standards and attention to health issues, C-PC being a functional food is preferred by more and more people. C-PC is easy to get, safe, and nontoxic; thus, it has a great potential of research and development as a drug or functional food. Here, the separation and purification, physicochemical properties, physiological and pharmacological activities, safety, and some applications are reviewed to provide relevant basis for the development of natural medicine and applied products.

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“…Li et al [30] have reported that C-PC is an ideal cancer prevention drug as it may inhibit the growth of cancer cells in vivo and in vitro . Thus, C-PC may become a good substitute for highly toxic conventional chemotherapeutic anticancer drugs in the future [31]. …”

Section: Introductionmentioning

confidence: 99%

Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 CellsIn VitroandIn Vivo

Bingula

Dupuis

Pichon

et al. 2016

Journal of Oncology

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We investigated the effects of betaine, C-phycocyanin (C-PC), and their combined use on the growth of A549 lung cancer both in vitro and in vivo. When cells were coincubated with betaine and C-PC, an up to 60% decrease in viability was observed which is significant compared to betaine (50%) or C-PC treatment alone (no decrease). Combined treatment reduced the stimulation of NF-κB expression by TNF-α and increased the amount of the proapoptotic p38 MAPK. Interestingly, combined treatment induced a cell cycle arrest in G2/M phase for ~60% of cells. In vivo studies were performed in pathogen-free male nude rats injected with A549 cells in their right flank. Their daily food was supplemented with either betaine, C-PC, both, or neither. Compared to the control group, tumour weights and volumes were significantly reduced in either betaine- or C-PC-treated groups and no additional decrease was obtained with the combined treatment. This data indicates that C-PC and betaine alone may efficiently inhibit tumour growth in rats. The synergistic activity of betaine and C-PC on A549 cells growth observed in vitro remains to be further confirmed in vivo. The reason behind the nature of their interaction is yet to be sought.

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Study of the synergistic effects of all-transretinoic acid and C-phycocyanin on the growth and apoptosis of A549 cells

Cited by 18 publications

References 0 publications

The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells

The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells

Medical Application of Spirulina platensis Derived C‐Phycocyanin

Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 CellsIn VitroandIn Vivo

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