Alloy 600 was studied from three aspects including corrosion behaviour experiment in high temperature, metallurgy element dissolving experiment and water chemistry optimization analysis. Experimental results showed that there was not obvious corrosion velocity for Alloy 600 in local concentrated NaOH solution; high ratio of iron dissolving concentration was found after high P,T experiment, which indicated that Alloy 600 experienced de-alloy corrosion in localized concentrated environment.