Study on improvement of chiral separation of capillary electrophoresis based on cyclodextrin by deep eutectic solvents

“…These results indicate that the NADES is successfully prepared based on the hydrogen bonding between ChCl and D-(−)-fructose. 24 Then, the NADES-assisted synthesized CCDs were characterized. HRTEM and AFM were used to study the nanostructure of CCDs.…”

Section: Characterizationmentioning

confidence: 99%

Natural deep eutectic solvent assisted synthesis and applications of chiral carbon dots

Wang

Zhou

et al. 2022

Green Chem.

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“…Recently chiral ILs have been the focus of an intense interest as additives for their synergistic effect on CD-driven enantioseparations [ 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ], and in some instances, for functionalization of the CDs [ 113 , 114 ]. The synergistic effect on the chiral separation by CDs has recently been reported by the utilization of eutectic solvents [ 115 , 116 , 117 ].…”

Section: Recent Advances In the Development Of Ce Analytical Procedur...mentioning

confidence: 99%

New Trends in the Quality Control of Enantiomeric Drugs: Quality by Design-Compliant Development of Chiral Capillary Electrophoresis Methods

et al. 2022

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Capillary electrophoresis (CE) is a potent method for analyzing chiral substances and is commonly used in the enantioseparation and chiral purity control of pharmaceuticals from different matrices. The adoption of Quality by Design (QbD) concepts in analytical method development, optimization and validation is a widespread trend observed in various analytical approaches including chiral CE. The application of Analytical QbD (AQbD) leads to the development of analytical methods based on sound science combined with risk management, and to a well understood process clarifying the influence of method parameters on the analytical output. The Design of Experiments (DoE) method employing chemometric tools is an essential part of QbD-based method development, allowing for the simultaneous evaluation of experimental parameters as well as their interaction. In 2022 the International Council for Harmonization (ICH) released two draft guidelines (ICH Q14 and ICH Q2(R2)) that are intended to encourage more robust analytical procedures. The ICH Q14 guideline intends to harmonize the scientific approaches for analytical procedures’ development, while the Q2(R2) document covers the validation principles for the use of analytical procedures including the recent applications that require multivariate statistical analyses. The aim of this review is to provide an overview of the new prospects for chiral CE method development applied for the enantiomeric purity control of pharmaceuticals using AQbD principles. The review also provides an overview of recent research (2012–2022) on the applicability of CE methods in chiral drug impurity profiling.

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“…The most effective methods for enantioseparation are chromatography, including gas chromatography (GC), 16 high performance liquid chromatography (HPLC), 17 supercritical fluid chromatography (SFC), 18 capillary electrophoresis (CE), 19 capillary electrochromatography (CEC), 20 etc. Among them, CEC is a powerful separation technique that combines the high selectivity of HPLC and the high separation efficiency of CE.…”

Section: Introductionmentioning

confidence: 99%

l-Cysteine modified metal–organic framework as a chiral stationary phase for enantioseparation by capillary electrochromatography

Gao

Qin

et al. 2022

RSC Adv.

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Study on improvement of chiral separation of capillary electrophoresis based on cyclodextrin by deep eutectic solvents

Cited by 45 publications

References 39 publications

Natural deep eutectic solvent assisted synthesis and applications of chiral carbon dots

Natural deep eutectic solvent assisted synthesis and applications of chiral carbon dots

New Trends in the Quality Control of Enantiomeric Drugs: Quality by Design-Compliant Development of Chiral Capillary Electrophoresis Methods

l-Cysteine modified metal–organic framework as a chiral stationary phase for enantioseparation by capillary electrochromatography

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