In this paper, the flow stress curves of YQ450NQR1 low carbon (wt. 0.12%) vanadium micro-alloyed YQ450NQR1 steel are obtained by conducting isothermal compression tests using Gleeble-1500 thermal simulation machine covering the temperature range of 1143K-1433K. To better describe the complex and abrupt deformation during the hot rolling process of the "Z-shaped" YQ450NQR1 products used for train beams, three deformation strain rates (1s -1 , 10 s -1 and 30s -1 ) are selected to study the hot deformation behavior. On this basis, a constitutive model considering deformation activation energy is established from the experimental stress-strain data. The model is further validated against multiple sets of hot compression test data and shows a good accuracy between predicted and tested flow stress with a correlation coefficient of 0.988 and an average error of 8.4%, which indicates the accuracy and reliability of the constitutive model for YQ450NQR1 steel.