Study on the mechanism of Gegen Qinlian Decoction for treating type II diabetes mellitus by integrating network pharmacology and pharmacological evaluation

Xu, Xinyi; LuLu, Niu; Liu, Yan; Pang, Meilu; Lu, Wanying; Xia, Cong Yuan; Zhu, Yuxuan; Yang, Bing‐You; Wang, Qi

doi:10.1016/j.jep.2020.113129

Cited by 30 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Network pharmacology and bioinformatics analysis indicated that GQD regulated 82 corresponding proteins and 59 relevant biological pathways associated with diabetes (Xu et al, 2020). NMR-based metabolomic studies revealed that GQD (4 or 8 g/kg/ d of oral water extract for five weeks; 300 mg/kg/d of metformin was used as positive control) significantly ameliorated disturbance in the glucose metabolism, tricarboxylic acid cycle, lipid metabolism, amino acid metabolism, gut microbial metabolism, and N-acetyl group metabolism of five to seven T2DM model rats (Tian et al, 2013).…”

Section: Nonalcoholic Fatty Liver Diseasementioning

confidence: 99%

“…Studies have shown that GQD has antidiarrheal (Liu et al, 2019b;Hua et al, 2019), anti-colitis (Xu B.-L. et al, 2015;Li et al, 2016;Fan et al, 2019;Zhao Y. et al, 2020), anti-nonalcoholic fatty liver disease (NAFLD) Guo et al, 2017;Guo et al, 2018;Hao et al, 2020;Zhang et al, 2020), antidiabetic (Zhang et al, 2013;Cao et al, 2020;Tu et al, 2020), anti-lung injury (Ding et al, 2020;Shi et al, 2020), antitumor (Wang N. et al, 2015;Lv et al, 2019) and other pharmacological effects. Metabolomics (Tian et al, 2013;Hua et al, 2019), network pharmacology (Li et al, 2014b;Cao et al, 2020;Ding et al, 2020;Hao et al, 2020;Xu et al, 2020;Zhong et al, 2020), gut microbiota analysis Guo et al, 2018;Liu et al, 2019b;Lv et al, 2019), and other methods have been comprehensively used to explain the action mechanism of GQD.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction

2021

Front. Pharmacol.

View full text Add to dashboard Cite

Gegen-Qinlian decoction (GQD) is a classic traditional Chinese medicine (TCM) formula. It is composed of four TCMs, including Puerariae Lobatae Radix, Scutellariae Radix, Coptidis Rhizoma, and Glycyrrhizae Radix et Rhizoma Praeparata cum Melle. GQD is traditionally and clinically used to treat both the “external and internal symptoms” of diarrhea with fever. In this review, key words related to GQD were searched in the Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), and other databases. Literature published mainly from 2000 to 2020 was screened and summarized. The main constituents of GQD could be classified into eight groups according to their structures: flavonoid C-glycosides, flavonoid O-glucuronides, benzylisoquinoline alkaloids, free flavonoids, flavonoid O-glycosides, coumarins, triterpenoid saponins, and others. The parent constituents of GQD that enter circulation mainly include puerarin and daidzein from Puerariae Lobatae Radix, baicalin and wogonoside from Scutellariae Radix, berberine and magnoflorine from Coptidis Rhizoma, as well as glycyrrhetinic acid and glycyrrhizic acid from Glycyrrhizae Radix et Rhizoma Praeparata cum Melle. GQD is effective against inflammatory intestinal diseases, including diarrhea, ulcerative colitis, and intestinal adverse reactions caused by chemotherapeutic agents. Moreover, GQD has significant effects on metabolic diseases, such as nonalcoholic fatty liver and type 2 diabetes. Furthermore, GQD can be used to treat lung injury. In brief, the main constituents, the pharmacokinetic and pharmacological profiles of GQD were summarized in this review. In addition, several issues of GQD including effective constituents, interactions between the constituents, pharmacokinetics, interaction potential with drugs and pharmacological effects were discussed, and related future researches were prospected in this review.

show abstract

Section: Nonalcoholic Fatty Liver Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction

2021

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Ohwi (gen), Scutellaria baicalensis Georgi (huang qin), Coptidis chinensis Franch (huang lian), and Glycyrrhiza uralensis Fisch (gan cao). GQD markedly decreased blood glucose and increased serum insulin levels in type II diabetic mice ( Xu et al, 2020 ). Since diabetes is a risk factor for AD ( Jash et al, 2020 ), this plant's extracts could be useful to diminish the risk of AD in persons having a propensity to develop diabetes due to genetic background ( Jash et al, 2020 ).…”

Section: Estrogenic Plants and Compounds With Potential Effects Against Alzheimer's Diseasementioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

View full text Add to dashboard Cite

In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging.

show abstract

“…ex DC (Gancao) (Zhang et al, 2013;. Based on the analysis of pathogenesis in MWM, GGQLD prevented and treated obese metabolic disorders and improved T2DM and NASH (Zhang et al, 2013;Wang et al, 2015;Guo et al, 2017;Xu et al, 2020;. Effects of GGQLD were related to the regulation of glucose and lipid metabolism (Zhang et al, 2013;Sui et al, 2019;Tu et al, 2020), intestinal flora (Zhang et al, 2017;Guo et al, 2018;Liu et al, 2019), levels of SCFAs (Liu et al, 2019), and oxidant stress and inflammatory .…”

Section: Prevention and Treatment Strategiesmentioning

confidence: 99%

Mechanism and Basis of Traditional Chinese Medicine Against Obesity: Prevention and Treatment Strategies

et al. 2021

View full text Add to dashboard Cite

In the last few decades, the incidences of obesity and related metabolic disorders worldwide have increased dramatically. Major pathophysiology of obesity is termed “lipotoxicity” in modern western medicine (MWM) or “dampness-heat” in traditional Chinese medicine (TCM). “Dampness-heat” is a very common and critically important syndrome to guild clinical treatment in TCM. However, the pathogenesis of obesity in TCM is not fully clarified, especially by MWM theories compared to TCM. In this review, the mechanism underlying the action of TCM in the treatment of obesity and related metabolic disorders was thoroughly discussed, and prevention and treatment strategies were proposed accordingly. Hypoxia and inflammation caused by lipotoxicity exist in obesity and are key pathophysiological characteristics of “dampness-heat” syndrome in TCM. “Dampness-heat” is prevalent in chronic low-grade systemic inflammation, prone to insulin resistance (IR), and causes variant metabolic disorders. In particular, the MWM theories of hypoxia and inflammation were applied to explain the “dampness-heat” syndrome of TCM, and we summarized and proposed the pathological path of obesity: lipotoxicity, hypoxia or chronic low-grade inflammation, IR, and metabolic disorders. This provides significant enrichment to the scientific connotation of TCM theories and promotes the modernization of TCM.

show abstract

Study on the mechanism of Gegen Qinlian Decoction for treating type II diabetes mellitus by integrating network pharmacology and pharmacological evaluation

Cited by 30 publications

References 37 publications

Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction

Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Mechanism and Basis of Traditional Chinese Medicine Against Obesity: Prevention and Treatment Strategies

Contact Info

Product

Resources

About