In the rapidly evolving domain of global e-commerce, operational organizations are increasingly grappling with unprecedented competitive pressures and challenges in operational efficiency. This study investigates the integration of artificial intelligence (AI) and information management as a transformative approach to augment operational efficiency in e-commerce organizations. The research delves into the optimization of organizational structures, leveraging the predictive capabilities of key information facilitated by AI. A novel decision-making model, integrating AI techniques, is developed to address the limitations inherent in existing decision-making technologies. The model's efficacy is demonstrated through a detailed case study of an e-commerce platform, where objectives and constraints for optimizing e-commerce operational organizations are meticulously constructed. The research identifies critical optimization points, including resource allocation, inventory management, logistics distribution, and customer relationship management. A distinctive organizational operation decision-making model, synergizing with the established Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS), is proposed. This model focuses on optimizing variables pivotal to operational efficiency, with the dual goals of elevating efficiency and enhancing customer satisfaction. The findings underscore the significant role of AI technology in amplifying decision quality and boosting operational efficiency in e-commerce operational organizations, while also presenting potential applicability to a broader spectrum of organizational types.