Study on the role of gastric Helicobacter infection in gross pathological and histological lesions of the stomach in finishing pigs

Abstract

The prevalence of gastric Helicobacter infection in finishing pigs and the influence of this infection on gastric lesions was studied. Stomachs of 89 finishing pigs from 27 randomly selected herds were sampled at the slaughterhouse. Forty cases (Group A) were selected based upon the presence of gross pathological lesions in the pars oesophagea, and further 49 cases were obtained at random (Group B). Three samples of gastric tissue (junction of pars oesophagea and pars cardiaca, fundic area, and pyloric area) were collected from each stomach for histological and immunohistochemical examination. Helicobacter antigen was detected in 76 cases (85.4%). No association was found between the presence of Helicobacter in the stomach and the occurrence of gross pathological lesions in the pars oesophagea or gastritis detected on histological examination. However, a significant association was found between the occurrence of Helicobacter in the pyloric area and the presence of erosions/ulcers in the pars oesophagea (OR: 7.01, p = 0.022) in Group B. A significant association was also evident between the presence of Helicobacter and glandular lesions (dilatation of the glands + glandular abscess + degeneration of glandular epithelial cells). In conclusion, Helicobacter infection seems to be a contributing factor to pathological changes in the stomach of finishing pigs.

Detection of Helicobacter candidatus suis by pcr in oesophagogastric ulcers of swine in Italy

“…Some studies have found an association between these two events (Barbosa et al, 1995;Queiroz et al, 1996;Roosendaal et al, 2000;Choi et al, 2001), while others have not (Grasso et al, 1996;Krakowka et al, 1998;Melnichouk et al, 1999). Anyway, even if the presence of the microorganism is not strictly related to the ulcer development, it can play a role in the multifactorial aetiology of the disease (Szeredi et al, 2005).…”

Helicobacteriose em leitões: imuno-histoquímica em amostras colhidas por meio de gastroscopia

“…Esses resultados são concordantes com os encontrados por Szeredi et al (2005), que, por meio da IHQ, encontraram maior infecção na região cárdica, seguida da pilórica e da fúndica. Uma das vantagens dessa técnica é o diagnóstico de cepas predominantemente cocoides, que, nas colorações de rotina, são mais difíceis de serem observadas (McNulty et al, 2011).…”

“…e a ocorrência de úlceras gastroesofágicas em suínos tem sido controversa. Embora alguns autores (Szeredi et al, 2005;Proietti et al, 2010) tenham observado a relação entre a presença do Helicobacter spp. e a prevalência e a severidade das úlceras gástricas, outros não o fizeram (Ramis et al, 2007).…”

Alterações histológicas da pars esophagea de suínos e sua relação com Helicobacter spp.

“…2A) (Muggenburg et al, 1964;O'Brien, 1993;Szeredi et al, 2005). A frequência de alterações histológicas na pars esophagea encontrada neste estudo e os resultados obtidos em outras investigações com análise macroscópica sugerem que essas lesões são muito frequentes no rebanho suíno brasileiro (Monticelli et al, 1995;Carvalho et al, 1999;Yamasaki et al, 2006 (Park et al, 2003) e que a patogenia das lesões gástricas está relacionada à espécie infectante.…”

“…Há relatos que demonstram associação positiva entre as lesões gástricas e Helicobacter spp. (Barbosa et al, 1995;Young et al, 2001;Mall et al, 2004) enquanto em outros essa relação é inconsistente (Melnichouk et al, 1999;Krakowka et al, 2005;Szeredi et al, 2005). Em cães, há um estudo recente de prevalência de helicobactérias e alterações na mucosa gástrica de animais saudáveis (Moutinho et al, 2007).…”