Vermiculite is extensively utilized for several applications, including as a hydroponic substrate, for soil conditioning, oil cleansing, and addressing trace metal pollution. In this study, the expansion of natural vermiculite was easily achieved by utilizing hydrogen peroxide (H2O2) with the aid of microwave technology. The characterization of expanded vermiculite involved the use of X‐ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), nitrogen adsorption isotherm (BET), and energy dissipation X‐rays (EDX). The vermiculite has been enlarged to have a structure resembling flakes, and its surface area measures 73.9 m2/g. The adsorption of Alizarin Red S onto expanded vermiculite was investigated under varying conditions, such as pH, starting concentration, adsorbent content, and duration of exposure. The enlarged vermiculite achieved a maximum adsorption capacity of 182.5 mg/g for Alizarin Red S. Out of the three adsorption isotherm models, both the Freundlich and Temkin models accurately describe the adsorption of Alizarin Red S onto expanded vermiculite. When studying adsorption kinetics, the second‐order adsorption kinetic model is more appropriate than the first‐order adsorption kinetic model, as indicated by an R2 value of 0.8964.