Studying the Anti-Diabetic Effect of Gamma-Irradiated Pumpkin Seeds

Azeem, Amir

doi:10.17582/journal.pjz/20201104131155

Cited by 5 publications

(5 citation statements)

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“…Due to the presence of these bioactive nutrients, it is assumed to be used as a remedy for lowering blood cholesterol or depression [ 13 , 14 ]. Besides that, anti-diabetic, antiulcer, wound healing, antioxidant, and hepatoprotective properties of the seed of pumpkin have also been investigated [ [15] , [16] , [17] ]. The fresh leaves and flowers also harbor important bioactive compounds with pharmacological activities such as antimicrobial, antifungal, anti-mutagenic, antioxidant, hepato-protection, anti-hyperglycemic, antidepressant, and anti-inflammation [ 9 , [18] , [19] , [20] ].…”

Section: Introductionmentioning

confidence: 99%

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Nutritional characterization and antioxidant properties of various edible portions of Cucurbita maxima: A potential source of nutraceuticals

Jahan

Islam

Moulick

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

“…It is proved that natural antioxidants are more effective as well as possess no harmful effect on human health in comparison with synthetic ones [ 16 ]. Natural antioxidant compounds including carotenoids, tocopherols, flavonoids, phenolic acids, vitamin C, and some minerals are mostly found in vegetables and fruits [ 6 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional characterization and antioxidant properties of various edible portions of Cucurbita maxima: A potential source of nutraceuticals

Jahan

Islam

Moulick

et al. 2023

Heliyon

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“…Abnormal thyroid hormone levels have also been reported in diabetic patients by Gursoy and Tuncel (1999). Abdul Azeem et al (2021) have similarly reported decreases in thyroid hormone levels in alloxan induced diabetic male Wistar rats which were restored to normal upon stabilization of the blood glucose with γ-irradiated pumpkin seeds dried powder administration. The lowered T4 level observed in both reversed diabetic and diabetic animals' groups may reflect the selective effect of diabetes on thyroid hormone that may not be dependent on glucose gradation.…”

Section: -Discussionmentioning

confidence: 93%

Instability of Alloxan-Induced Diabetes and Its Impact on Sex and Thyroid Hormones in Male Wistar Rats-a Pilot Study

Osibemhe

Orji²,

Omaji³

et al. 2022

KJS publishes peer-review articles in Mathematics, Computer Sci

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The relationship between diabetes mellitus and sex and/or thyroid hormones has been well documented in both human and animal studies ditto auto-reversibility of alloxan. However, the correlation between unstable diabetes and these hormones has little or no information in the literature; hence, the focus of this study. Diabetes was induced with a single intraperitoneal injection of 150 mg/kg of freshly prepared alloxan. Twenty five adult male Wistar rats (weight 120-150 g) were used in this study. Alloxan was administered to 20 rats and 5 rats served as control. Alloxan-administered rats were further divided into two groups. One group (diabetic rats) was used as diabetic control and the other group served as reversed diabetic, which contained rats whose fasting blood glucose was confirmed to be normoglycemic post-diabetic. All rats were maintained on normal rat feed and water ad libitum and were monitored for 14 days. Blood glucose was monitored at intervals of 7 days after basal (before diabetes induction) and day 1(diabetes confirmation) values had been noted. Sex hormones: Luteinizing hormone (LH), follicle stimulating hormone (FSH), and estrogen (E) as well as thyroid hormones: Triiodothyronine (T3), tetraiodothyronine (T4) and thyroid stimulating hormone (TSH) were assayed after 14 days. Alloxan caused alteration in blood glucose levels of both diabetic and reversed diabetic groups. T4 level was lowered significantly in both diabetic (11.32 ± 0.26 μg/ml) and reversed diabetic (11.00 ± 0.16 μg/ml) groups in relation to the control. Other assayed hormones were not different significantly from the control. These findings indicate that influence of diabetes on these hormones may not be dependent on glucose gradation.

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“…The irradiation does not have a substantial impact on the irradiated fungal mycelium (Duan et al, 2010). This increase can be associated with the radiation dose, as it was found that high doses of radiation led to an expansion in TPC and TF in pumpkin (Abdul Azeem et al, 2022).…”

Section: Phenols Flavonoids Total Soluble Sugars and Reducing Sugarsmentioning

confidence: 99%

Gamma Irradiation-Mediated Alterations in Chemical Composition and Antimicrobial Efficacy of Zubaidi, a Wild Edible Desert Truffle (Terfezia boudieri), with Implications for Pharmaceutical Applications

ALTAMIM

2024

Food Sci. Technol (Campinas)

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In exploring the impact of γ-radiation on the biochemical makeup and antimicrobial attributes of Zubaidi truffle (Terfezia boudieri), this study delved into the nuanced interplay between irradiation doses, chemical components, and antimicrobial efficacy. This research scrutinized the influence of γ-radiation on the chemical constitutes and antimicrobial characteristics of Zubaidi truffle (Terfezia boudieri). By applying four distinct doses of γ-radiation (2.5, 5.0, 7.5, and 10 kGy), the study assesses various parameters, including phenols, flavonoids, total and reduced soluble sugars, crude and soluble protein, total amino acids, antioxidant activity, and the susceptibility of examined strains to irradiated and non-irradiated truffle extracts in comparison to standard antibiotics. The findings elucidate that γ-irradiation induces moderate adjustments in the chemical composition, coupled with a dose-dependent escalation in antioxidant activity. Remarkably, irradiated truffle extracts highlight antibiotic efficacy comparable to standard antibiotics, unveiling a nuanced correlation influenced by both radiation dosage and bacterial strain.

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Studying the Anti-Diabetic Effect of Gamma-Irradiated Pumpkin Seeds

Abstract: Authors' Contribution All authors contributed to the study design. YZ, SR and MX collected samples and analyzed the data. YZ prepared the first draft of the manuscript. YZ, NLand XZ performed the experiments. CH and XN revised the article.

Cited by 5 publications

References 0 publications

Nutritional characterization and antioxidant properties of various edible portions of Cucurbita maxima: A potential source of nutraceuticals

Nutritional characterization and antioxidant properties of various edible portions of Cucurbita maxima: A potential source of nutraceuticals

Instability of Alloxan-Induced Diabetes and Its Impact on Sex and Thyroid Hormones in Male Wistar Rats-a Pilot Study

Gamma Irradiation-Mediated Alterations in Chemical Composition and Antimicrobial Efficacy of Zubaidi, a Wild Edible Desert Truffle (Terfezia boudieri), with Implications for Pharmaceutical Applications

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