Studying the result of underlay myringoplasty using platelet-rich plasma

Abstract

ObjectivePerforations of the tympanic membrane are treated with various surgical techniques and materials. This study aimed to determine the efficacy of platelet-rich plasma during underlay myringoplasty.MethodsThe study included 40 patients. Autologous platelet-rich plasma was applied in-between temporalis fascia graft and tympanic membrane remnant during underlay myringoplasty in group 1 (n = 20). The outcome was evaluated after three months and compared with group 2 (n = 20), a control group that underwent routine underlay tympanoplasty.ResultsAfter three months’ follow up, graft uptake was 95 per cent in group 1 and 85 per cent in group 2 (p < 0.03). Mean hearing threshold gain was 18.62 dB in group 1 and 13.15 dB in group 2. This difference was statistically significant (p < 0.01).ConclusionPlatelet-rich plasma, with its ease of preparation technique, availability, low cost, autologous nature and good graft uptake rate, justifies its use in tympanoplasty type I procedures.

Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis

“…Of the 34 nonrepetitive studies identified, eight studies [8][9][10][11][12][13][14][15] including 455 participants with different sizes of TM perforations were eligible for final selection after screening the full texts. These included studies published from 2015 to July 2020 and consisted of five RCTs [9,10,[12][13][14], one prospective study [15], and two retrospective studies [8,11]. Seven of the included studies [8][9][10][12][13][14][15] compared the efficacy of PRP with conventional tympanoplasty or myringoplasty.…”

“…These included studies published from 2015 to July 2020 and consisted of five RCTs [9,10,[12][13][14], one prospective study [15], and two retrospective studies [8,11]. Seven of the included studies [8][9][10][12][13][14][15] compared the efficacy of PRP with conventional tympanoplasty or myringoplasty. Among the seven studies in which the experimental groups received PRP three involved fat graft myringoplasty (FGM) [8,9,14], one used conchal perichondrium myringoplasty (PM) [13], and three involved temporalis fascia tympanoplasty (TFT) [10,12,15].…”

“…Seven of the included studies [8][9][10][12][13][14][15] compared the efficacy of PRP with conventional tympanoplasty or myringoplasty. Among the seven studies in which the experimental groups received PRP three involved fat graft myringoplasty (FGM) [8,9,14], one used conchal perichondrium myringoplasty (PM) [13], and three involved temporalis fascia tympanoplasty (TFT) [10,12,15]. Among the control groups, two group underwent FGM [8,14], and one group underwent PM [13].…”

“…Among the control groups, two group underwent FGM [8,14], and one group underwent PM [13]. The other four groups of patients underwent tympanoplasty surgery [9,10,12,15]. The…”

“…Based on previous evidence, PRP contains many growth factors (e.g., platelet-derived growth factor, PDGF), accelerating the regeneration of endothelial tissue and enhancing tissue healing. [7][8][9][10][11][12][13][14][15][16] Although the majority of human trials have reported promising benefits [8][9][10][11][12][13][14][15], the completed closure rate varies across studies, and the outcomes of both healing and hearing improvements require further evaluation. To the best of our knowledge, no systematic analysis has been performed to compare the efficacy of PRP in TM regeneration surgeries.…”