Su1037 Prevalence and Risk Factors of Nonalcoholic Fatty Liver Disease in a Rural Community of South Asia

Rahman, Mohammed M.; Kibria, Md. Golam; Begum, Hasina; Haque, Mazhar; Sultana, Nigar; Akhter, Mahfuza; Rowshon, Ahm; Ahmed, Faruque; Hasan, Mahmud

doi:10.1016/s0016-5085(15)33567-8

Cited by 10 publications

(16 citation statements)

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“…In this study binary logistic regression analysis explored that diabetes, obesity (BMI>25), increased waist circumference and hypertriglyceridemia are independent risk factors for development of NAFLD. 22 This is the 2 nd commonest cause of hepatology out-patient consultation in the country after chronic hepatitis B. 23 These data are in concordance with prevalence of neighboring countries.…”

Section: Burden Of Nafld In Bangladeshmentioning

confidence: 58%

“…15 Prevalence of NAFLD in general population of Bangladesh has been estimated to vary from 4 to 18.4 %, which jumps up to 49.8% in diabetic patients. 21,22 Rahman et al in their rural population based study revealed prevalence of 18.4% with a higher prevalence of 59.4% in diabetic patients. In this study binary logistic regression analysis explored that diabetes, obesity (BMI>25), increased waist circumference and hypertriglyceridemia are independent risk factors for development of NAFLD.…”

Section: Burden Of Nafld In Bangladeshmentioning

confidence: 92%

“…Unique character of NAFLD in Bangladesh: Though NAFLD appears to be a disease of the obese, in Bangladesh non-obese populations are also affected and the severity is also similar to that found in obese population. 22,27,28 Though NAFLD is a male predominating disease in Europe and USA, it appears to affect Bangladeshi females more than males. Social conservative attitude leading to sedentary life style of the female may be responsible for this.…”

Section: Burden Of Nafld In Bangladeshmentioning

confidence: 99%

“…29,30 Affluence is another reason for development of NAFLD. 22 The child and adolescent populations of urban society with very little physical activity will constitute the future burden of NAFLD in the country in near future. ALT as well as GGT is good detector of NASH in Bangladeshi population with GGT having better sensitivity and specificity.…”

Section: Burden Of Nafld In Bangladeshmentioning

confidence: 99%

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Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

Alam

Hossain

Azam

et al. 2017

J. Bangladesh Coll. Phys.

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Nonalcoholic Fatty Liver Disease (NAFLD) is the condition where fat accumulates in liver without significant ingestion of alcohol. NAFLD has become one of the most common liver conditions throughout the world. At the dawn of the history of NAFLD it was thought that NAFLD is disease of obese individual but lean patients are increasingly detected to have NAFLD. It seems that insulin resistance is central to the pathogenesis of NAFLD. In addition, oxidative stress and cytokines are important contributing factors, resulting in steatosis and progressive liver damage in genetically susceptible individuals. NAFLD varies considerably by ethnic group and Bangladeshi ethnicity is an independent risk factor for NAFLD. Prevalence of NAFLD in general population of Bangladesh is 4 -18.4 %, which jumps up to 49.8% in diabetic patients. With the changes in socioeconomic condition and life style, aetiology of chronic liver disease is drifting from infectious to noninfectious diseases and the contribution of NAFLD is progressively increasing. Hepatitis B and hepatitis C have been the leading causes of mortality and morbidity from chronic liver disease in Bangladesh. But with increase in awareness and mass vaccination against HBV, prevalence of both the diseases has been decreasing in the country. The most alarming feature is that there is a high prevalence of NASH among the NAFLD patients. NAFLD is emerging as the largest contributor of chronic liver disease in Bangladesh. This warrants the attention of health policy makers and clinicians to explore this frontier and combat it from right now.

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Section: Burden Of Nafld In Bangladeshmentioning

confidence: 58%

Section: Burden Of Nafld In Bangladeshmentioning

confidence: 92%

Section: Burden Of Nafld In Bangladeshmentioning

confidence: 99%

Section: Burden Of Nafld In Bangladeshmentioning

confidence: 99%

See 2 more Smart Citations

Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

Alam

Hossain

Azam

et al. 2017

J. Bangladesh Coll. Phys.

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“…The prevalence of NAFLD was the most frequently recorded liver disease and was most common among Bangladeshi patients [5]. Prevalence of NAFLD in general population of Bangladesh has been estimated to vary from 4 to 18.4 %, which jumps up to 49.8% in diabetic patients [24,25].…”

Section: Prevalence Of Hepatitis B and Fatty Liver Among Bangladesh Popmentioning

confidence: 99%

Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

Alam¹

2017

GHOA

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Chronic hepatitis B (HBV) is one of the major diseases of mankind, estimated to cause about 686,000 deaths per year mostly from liver cancer and cirrhosis. And globally about 240 million people are chronically infected with hepatitis B. Nonalcoholic fatty liver disease (NAFLD) is an emerging commonest cause of chronic liver disease in the world. We have searched for CHB, NAFLD in PUBMED, Google scholar and local journals and related available articles were included in this review. Along with 184 countries of the world Bangladesh adopted hepatitis B vaccine in his EPI (expanded program on immunization) schedule for its prevention. And now about 95% of children are under cover of Hepatitis vaccine. Along with globally in last two decades' seroprevalence of HBsAg reduced about four times in Bangladesh. The prevalence of recorded nonalcoholic fatty liver disease (NAFLD) varies considerably by ethnic group and Bangladeshi ethnicity is an independent risk factor for NAFLD. The prevalence of NAFLD in Bangladesh is vary from 4%-18.4% and it is increasing day by day. About 40% of them are nonalcoholic steatohepatitis (NASH). They are in danger of progression to cirrhosis and hepatocellular carcinoma (15-19%) in next 5 to 10 years. Now it's becoming a silent killer for our nation. Gradual development of affluence, sedentary life style and increasing prevalence of diabetes contributed behind it. No effective treatment is available till now. Life style change by diet, exercise and weight reduction is the main stay of treatment. NAFLD involve multiple organs that leads to death due to cardiac, neurological and liver disease. Government and health department should take multidisciplinary action programs in awareness building and make a national guideline for fatty liver management.

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Prevalence and risk factors of non‐alcoholic fatty liver disease in Bangladesh

et al. 2018

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Background and AimNon‐alcoholic fatty liver disease (NAFLD) is a significant cause of hepatic dysfunction and liver‐related mortality. As there is a lack of population‐based prevalence data in a representative sample of general population, we aimed to estimate the prevalence and risk factors of NAFLD in Bangladesh.MethodsA cross‐sectional study was conducted both in urban and rural areas of Bangladesh from December 2015 to January 2017. Data were collected using a pretested structured questionnaire followed by ultrasonography of hepatobiliary system for screening of NAFLD. Multivariate logistic regression was used to estimate the risk factors of NAFLD.ResultsA total of 2782 (1694 men and 1088 women) participants were included in the study, with a mean age of 34.21 (±12.66) years. The overall prevalence of NAFLD was 33.86% (95% confidence interval [CI]: 32.12, 35.64). Females living in the rural areas and midlife adults (45–54 years) had the highest prevalence of NAFLD (P < 0.05). Multivariable logistic regression model demonstrated that increasing age, diabetes, elevated body mass index, and married individuals are significantly associated with NAFLD. Individuals with diabetes (adjusted odds ratio: 2.71, 95% CI: 1.85, 3.97) and hypertension were at a higher risk of having NAFLD. The odds of having NAFLD were 4.51 (95% CI: 3.47, 5.86) and 10.71 (95% CI: 7.80, 14.70) times higher among overweight and obese participants, respectively, as compared to normal‐weight participants.ConclusionsAbout one‐third of the population of Bangladesh is affected by NAFLD. Individuals with higher body mass index (overweight and obese), diabetics, midlife adults, married individuals, and rural women were more at risk of having NAFLD than others.

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Su1037 Prevalence and Risk Factors of Nonalcoholic Fatty Liver Disease in a Rural Community of South Asia

Cited by 10 publications

References 0 publications

Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

Prevalence and risk factors of non‐alcoholic fatty liver disease in Bangladesh

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