Su1987 Methylated Reprimo in Cell-Free DNA (RPRM) in Comparison With CEA and CA 19-9 As a Tumor Marker in Gastric Cancer

Corvalán, Alejandro; Garrido, Marcelo; Maturana, María J.; Corsi, Oscar; Ledermann, Gerardo

doi:10.1016/s0016-5085(15)31916-8

Gastroenterology

2015

DOI: 10.1016/s0016-5085(15)31916-8

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Su1987 Methylated Reprimo in Cell-Free DNA (RPRM) in Comparison With CEA and CA 19-9 As a Tumor Marker in Gastric Cancer

Alejandro Corvalán¹,

Marcelo Garrido²,

María J. Maturana³

et al.

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2018

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“… 2 , 3 Reprimo is one of the genes responsible for regulation of development and growth of normal cells. 4 Deactivation of Reprimo gene usually takes place in initial phases of various tumors mostly as a result of DNA methylation. 5 It has been greatly observed that in two cell categories of gastric cancer without Reprimo methylation, weak expression in normal conditions and high expression in cases of DNA damage were observed.…”

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Studying the expression rate and methylation of Reprimo gene in the blood of patients suffering from gastric cancer

Abbasi¹,

Heydari²

2018

Eur J Transl Myol

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As gastric cancer has no exclusive signals in its initial phases, it is usually diagnosed in advanced phases. Although many researches have been conducted on methylation and diagnosis of cancer’s markers, the methylation and expression of Reprimo gene and its correlation with gastric cancer has not been thoroughly studied. Methylation of Reprimo promoter is a repetitive procedure exclusive to cancer which nullifies its expression and performance. The present research seeks to study the expression and methylation of Reprimo among people suffering with gastric cancer so that it may be used as a biomarker for early diagnosis. Fifty blood samples taken from healthy people (normal samples) and 50 blood samples obtained from gastric cancer patients were analyzed using Real-Time PCR. The methylation status of the promoter of Reprimo was studied using Methylation Specific PCR technique in normal samples and in gastric cancer Iranian patients. We observed reduction in expression rate of Reprimo in the blood samples of patients suffering with gastric cancer in comparison to normal blood samples. A significant correlation was also observed between the expression rate of this gene, age and methylation of its promoter among patients suffering with gastric cancer and various analysis points to a correlation between reduced expressions of Reprimo gene in gastric cancer patients. In conclusion, reduced expression of Reprimo gene and greater levels of methylation of its promoter seems to be promising biomarkers for early diagnosis of gastric cancer.

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mentioning

confidence: 99%

Studying the expression rate and methylation of Reprimo gene in the blood of patients suffering from gastric cancer

Abbasi¹,

Heydari²

2018

Eur J Transl Myol

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Su1987 Methylated Reprimo in Cell-Free DNA (RPRM) in Comparison With CEA and CA 19-9 As a Tumor Marker in Gastric Cancer

Cited by 1 publication

References 0 publications

Studying the expression rate and methylation of Reprimo gene in the blood of patients suffering from gastric cancer

Studying the expression rate and methylation of Reprimo gene in the blood of patients suffering from gastric cancer

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