Sub-chronic effect of Rambo insect powder contaminated diet on superoxide dismutase (SOD) activity in Wister albino rats

Abstract

Studies of superoxide dismutase (SOD) induction in rats exposed to locally produced insecticide, "Rambo" of which the active chemical compound is permethrin (0.6% w/w) was performed. The rats were divided into three groups of five rats per cage. Each group of rats was fed with normal diet contaminated with 1 %, 5 % and 10 % (w/w) of the insecticide respectively. The control group was fed normal diet. The effect of insecticide at various concentrations on superoxide dismutase (SOD) activity in the blood plasma was not significantly different (P > 0.05) in the newly weaned rats (NWR). However, in the middle-aged rats (MAR) and aged rats (AR) groups, the results were significantly different (P < 0.05) against the parallel controls. Comparison of the effect of the insecticide on SOD induction at various concentrations among the groups based on age difference showed significantly different result (P < 0.05), especially among the groups fed with 10 % (w/w) of the insecticide in the diet. Results of this study show that in non-target organisms "Rambo" insect powder may induce superoxide dismutase activity thus suggesting oxidative-stress related toxicity.

Biochemical and histological changes in liver and kidney in male Wistar albino rats following exposure to Solignum®: a permethrincontaining wood preservative

“…The common uses of permethrin-containing insecticides have resulted in different forms of diseases that are consistent with the observed effects in the present study. 6 In the present study, the oral administration of the commercial wood preservative-Solignum ® , a permethrin-containing insecticide showed no mortality or physical changes up to 1/10 of the higher range of the LD 50 for permethrin in rats. This corroborates earlier reports that the no-observed-adverse-effect-level is greater than 400 mg/kg BW.…”

“…In the tropics, insecticide nets are often treated with pyrethroids as part of efforts in combating the scourge of Malaria. 5 Both agricultural and domestic uses of insecticides have resulted in different forms of diseases, 6 and the effects are not only limited to the immediate users. Although they have high selectivity for insects 7 several studies have described the adverse effects of pyrethroids on different organs and systems of the body, such as the liver, gastro-intestinal, respiratory, nervous and immune systems.…”

Histological effects of permethrin insecticide on the testis of adult wistar rats

“…In the tropics, insecticide nets are often treated with pyrethroids as part of efforts in combating the scourge of Malaria (3). Both agricultural and domestic uses of pesticides and insecticides have resulted in different forms of diseases (4), and the effects are not only limited to the immediate users. Although they have high selectivity for insects (5), several studies have described the adverse effects of pyrethroids on the different organs and systems of the body, such as the liver, gastro-intestinal, respiratory, nervous and immune systems.…”

Biomarkers of Pesticide - Contaminated Environment

“…SOD is an important isoenzyme functioning as superoxide radicals' scavenger in the living organisms. It is an important enzyme family in living cells for maintaining normal physiological conditions and coping with stress (Otitoju 2005). The action of SOD therefore results in the protection of biological integrity of cells and tissues against the harmful effects of superoxide free radicals (Olusi, 2000).…”