“…Girls seem generally to be Th1 deviated, in contrast to boys which seem to be more Th2 deviated [155,156]. In many affected individuals CD remains undiagnosed, but the rate of diagnosis is increasing due to the frequent screening for the disease [142,143,[157][158][159][160][161][162][163]. Thus, screening studies are an important tool for detection of asymptomatic CD, which confers reduced risks for long term complications.…”