Subclinical hypothyroidism in pregnancy: An emerging problem in Southern West Bengal: A cross-sectional study

Mandal, Ratan Chandra; Bhar, Debasish; Das, Anjan; Basunia, Sandip Roy; Kundu, Sudeshna Bhar; Mahapatra, Chinmay

doi:10.4103/0976-9668.175080

Cited by 13 publications

(7 citation statements)

References 24 publications

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“…The prevalence of subclinical hypothyroidism in pregnancy in our study was 27.3 % when the upper reference limit of TSH value taken as 2.5 mlU/L in the first trimester and 3 mlU/L in second and third trimester. Mandal RC et al and Panda J et al in their study reported its prevalence of 37.15 % and 32.94 % when 2.5 mIU/L taken as cut off in the TSH level [12,13]. Prevalence of subclinical hypothyroidism in pregnancy in the present study was 6.36 % when the upper reference limit of the TSH value taken as 4 mIU/L in all trimester of pregnancy as per recent ATA (2017) guideline.…”

Section: Discussionsupporting

confidence: 57%

Study on thyroid function test in pregnancy in a tertiary care hospital

et al. 2021

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Thyroid disorder is a very common endocrine problem encountered by pregnant women. Maternal thyroid dysfunction is associated with adverse outcome both in mother and fetus. The aim of the study: to find out the prevalence of various thyroid disorders in pregnant women attending antenatal clinic. Materials and methods. This prospective cross-sectional study was carried out in the Department of Obstetrics and Gynecology, F.M. Medical College & Hospital, Balasore, Odisha from June 2020 to May 2021. 220 women with uncomplicated singleton pregnancy were included. Serum Thyroid-stimulating hormone (TSH), free T4 (FT4) and free T3 (FT3) were estimated by using electro-chemiluminescence immunoassay technique. Results. Out of 220 pregnant women screened for thyroid dysfunction, 68 were found to have thyroid disorders. 27.3 % of pregnant women had subclinical hypothyroidism, 1.4 % had overt hypothyroidism, 1.8 % had subclinical hyperthyroidism and 0.5 % had overt hyperthyroidism. Prevalence of subclinical hypothyroidism was 6.36 % when the upper reference limit of TSH level taken as 4 mIU/L. Prevalence of thyroid disorder among pregnant women in the age groups 18–25 years, 26–30 years and 31–40 years were 28.9 %, 32.1 % and 38.9 % respectively. There were 35.5 %, 28 % and 26 % pregnant women with thyroid disorders in the first, second and third trimester respectively. Prevalence of both subclinical and overt hypothyroidism were more in multigravida compared to primigravida. Conclusion. Our study revealed high prevalence of thyroid disorders in pregnant women and maternal subclinical hypothyroidism was the most common pattern.

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Section: Discussionsupporting

confidence: 57%

Study on thyroid function test in pregnancy in a tertiary care hospital

et al. 2021

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“…In a study by Mandal et al,32.94% of the pregnant mothers had subclinical hypothyroidism and anti-TPO Ab positivity was found in 12.15% of the study population and in 33.93% of the SCH pregnant women [45]. Thus, it is evident that the prevalence of SCH varies widely in different parts of the country among pregnant women.…”

Section: Discussionmentioning

confidence: 86%

“…The prevalence of SCH in pregnancy differs extensively worldwide [41]. In India, the prevalence of SCH varies from 2.8% to 32.94% in different parts of the country, as documented in various studies [42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Subclinical Hypothyroidism in Pregnancy and Its Association With Anti-thyroperoxidase Antibody and the Occurrence of Gestational Diabetes Mellitus

Dash¹,

Tiwari²,

Nayak³

et al. 2022

Cureus

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ConclusionAnti-TPO antibody subsequently leads to hypothyroxinemia, for which it is necessary that cases with high titer of anti-TPO antibody though euthyroid should be meticulously followed up and screened for to detect development of hypothyroidism or SCH, particularly in future pregnancies. However, GDM prevalence was at par with the national figure, but with no significant association of SCH and a high anti-TPO ab titer was found with GDM in our study. Further studies with a larger cohort may establish a causal association between the two most common endocrinological disorders observed in pregnancy.

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“…Table 1 lists recently published data on this aspect of thyroidology. [ 4 5 6 7 8 9 10 11 12 13 14 15 16 17 ] It must be noted that there is a wide heterogeneity in results, probably due to differing TSH cut offs for diagnosis. Some studies with uncertain or unreliable methodology have not been included in the table.…”

Section: Discussion and C Onclusionmentioning

confidence: 99%

Prevalence of hypothyroidism in term pregnancies in North India

Kalra

Choudhary

Thakral

et al. 2018

Indian J Endocr Metab

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Background:Hypothyroidism is common in pregnancy. No study has determined the prevalence of hypothyroidism in term pregnancies in India.Aim:This study aims to determine the prevalence and correlates of hypothyroidism in women who delivered at a center in Karnal, Haryana, North India.Results:Indoor records of all women who had delivered at this centre from April 2016 to March 2017 were reviewed. The prevalence of hypothyroidism was 12.3%, of which 15.5% were diagnosed during pregnancy. The dose requirement of L-thyroxine ranged from 25 to 200 μg (mean 76.38 +- 43.02). With this, 80% were able to achieve trimester-specific thyroid-stimulating hormone targets. Hypothyroidism did not correlate with any medical or obstetric complications.Conclusion:Hypothyroidism is common in term pregnancies. If treated adequately, healthy fetomaternal outcomes can be achieved.

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Subclinical hypothyroidism in pregnancy: An emerging problem in Southern West Bengal: A cross-sectional study

Cited by 13 publications

References 24 publications

Study on thyroid function test in pregnancy in a tertiary care hospital

Study on thyroid function test in pregnancy in a tertiary care hospital

Prevalence of Subclinical Hypothyroidism in Pregnancy and Its Association With Anti-thyroperoxidase Antibody and the Occurrence of Gestational Diabetes Mellitus

Prevalence of hypothyroidism in term pregnancies in North India

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