The article presents the results of studies on the spread of various forms of endometritis in cows. Clinical acute and chronic forms of endometritis occurred in 15.17 and 8.99% of cows, respectively. The data obtained indicate the dominant distribution of subclinical endometritis in cows (32.02%). To conduct research, two experimental and one control groups of cows were formed. Animals of the first experimental group were injected intrauterine with the drug Metricef, the second experimental group - intramuscularly with the drug amoxicillin 150. The cows of the control group were not treated. The results of the studies showed the effectiveness of the use of amoxicillin 150. The method of intramuscular use of the amoxicillin preparation is much simpler and makes it possible to achieve fertilization of cows by 5.26% more compared to the intrauterine administration of the metricef preparation.