Subcortical substrates of TMS induced modulation of the cortico-cortical connectivity

Groppa, Sergiu; Otto, Birte; Deuschl, Günther; Siebner, Hartwig R.; Raethjen, Jan

doi:10.1016/j.brs.2012.03.014

Cited by 33 publications

(17 citation statements)

References 44 publications

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“…They are similar to those previously described in other TMS/EEG experiments, where TMS was applied to different regions of cortex (Paus et al, 2001; Komssi et al, 2002, 2004; Bonato et al, 2006; Lioumis et al, 2009; Zanon et al, 2010; Ferreri et al, 2011; Busan et al, 2012). Consistent with previous studies, EEG deviations from pre-stimulus baseline could be induced by activation of local and remote cortical neurons and/or synchronization of ongoing activity (e.g., Paus et al, 2001; Groppa et al, 2013). Further components should not be excluded, and in particular in the time windows not considered in the present analysis, for example those between 0 and 45 ms, which were removed because the recorded potentials were still corrupted by the electric artifact induced by the strong magnetic pulse.…”

Section: Discussionsupporting

confidence: 88%

Long-range neural activity evoked by premotor cortex stimulation: a TMS/EEG co-registration study

Zanon

Battaglini

Jarmolowska

et al. 2013

Front. Hum. Neurosci.

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The premotor cortex is one of the fundamental structures composing the neural networks of the human brain. It is implicated in many behaviors and cognitive tasks, ranging from movement to attention and eye-related activity. Therefore, neural circuits that are related to premotor cortex have been studied to clarify their connectivity and/or role in different tasks. In the present work, we aimed to investigate the propagation of the neural activity evoked in the dorsal premotor cortex using transcranial magnetic stimulation/electroencephalography (TMS/EEG). Toward this end, interest was focused on the neural dynamics elicited in long-ranging temporal and spatial networks. Twelve healthy volunteers underwent a single-pulse TMS protocol in a resting condition with eyes closed, and the evoked activity, measured by EEG, was compared to a sham condition in a time window ranging from 45 ms to about 200 ms after TMS. Spatial and temporal investigations were carried out with sLORETA. TMS was found to induce propagation of neural activity mainly in the contralateral sensorimotor and frontal cortices, at about 130 ms after delivery of the stimulus. Different types of analyses showed propagated activity also in posterior, mainly visual, regions, in a time window between 70 and 130 ms. Finally, a likely “rebounding” activation of the sensorimotor and frontal regions, was observed in various time ranges. Taken together, the present findings further characterize the neural circuits that are driven by dorsal premotor cortex activation in healthy humans.

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Section: Discussionsupporting

confidence: 88%

Long-range neural activity evoked by premotor cortex stimulation: a TMS/EEG co-registration study

Zanon

Battaglini

Jarmolowska

et al. 2013

Front. Hum. Neurosci.

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“…Although this study was performed with a figure-of-8 coil, the suggestion that hippocampal structures might be affected in the form of functional decoupling, especially with regard to the hippocampus as a key area of BDNF expression, may well explain our findings. Groppa et al [44] demonstrated in a combined neurophysiological and neuroimaging study that TMS of the primary MC modulates the contralateral thalamus and thalamocortical and transcallosal pathways, providing further evidence for the involvement of crucial brain structures.…”

Section: Discussionmentioning

confidence: 99%

Effects of Deep Repetitive Transcranial Magnetic Stimulation on Brain-Derived Neurotrophic Factor Serum Concentration in Healthy Volunteers

Gaede

Hellweg²,

Zimmermann³

et al. 2014

Neuropsychobiology

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Objective: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, safe and efficacious technique for treating various neuropsychiatric disorders, but its underlying mechanisms are poorly understood. A newly developed H-coil allows the stimulation of deeper brain regions. This study is the first to investigate the effects of deep high-frequency rTMS on brain-derived neurotrophic factor (BDNF) serum concentrations in healthy volunteers. We aimed to evaluate the short-term effect of deep rTMS on BDNF serum concentrations. Methods: This was a double-blind, randomized deep high-frequency rTMS study using an H-coil on a cohort of 13 healthy volunteers (NCT01106365). The following stimulation protocols were applied: 18-Hz stimulation of the left dorsolateral prefrontal cortex (PFC), 5-Hz stimulation of the primary motor cortex (MC) and sham stimulation in random order. Blood samples were obtained before, 30 min after and 60 min after each treatment. Results: The BDNF serum concentration decreased significantly after MC and PFC stimulation, but not after sham stimulation. Furthermore, BDNF serum level changes were associated with changes in individual alertness. Conclusion: Although BDNF serum concentrations do not necessarily correlate with BDNF levels in the cerebrospinal fluid or the brain, these results indicate an acute biological effect of deep rTMS on BDNF release, and demonstrate that this change correlates with alertness.

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“…(For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) (Fuggetta et al, 2005), which lasted up to 175 ms and linearly correlated with anatomical integrity of the thalamus contralateral to the stimulation site, and of the thalamo-cortical and transcallosal fibers (Groppa et al, 2013).…”

Section: Tms-evoked Eeg Oscillations Of the Motor Cortexmentioning

confidence: 99%

TMS and drugs revisited 2014

Ziemann

Reis

Schwenkreis

et al. 2015

Clinical Neurophysiology

568

583

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Subcortical substrates of TMS induced modulation of the cortico-cortical connectivity

Cited by 33 publications

References 44 publications

Long-range neural activity evoked by premotor cortex stimulation: a TMS/EEG co-registration study

Long-range neural activity evoked by premotor cortex stimulation: a TMS/EEG co-registration study

Effects of Deep Repetitive Transcranial Magnetic Stimulation on Brain-Derived Neurotrophic Factor Serum Concentration in Healthy Volunteers

TMS and drugs revisited 2014

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