Subcutaneous abdominal artificial tears pump-reservoir for severe dry eye

Murube, Juan; Murube, Eduardo; ChenZhuo, Lucia; Rivas, Luis Fernando

doi:10.1076/orbi.22.1.29.14012

Cited by 29 publications

(15 citation statements)

References 4 publications

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“…The signs and symptoms of dry eye, including severe blepharospasm, were dramatically improved in all 6 patients. 68 However, biofilm associated infection along the silicone tube is, in our opinion, likely to become a problem at some stage. 69−72 …”

Section: Subcutaneous Abdominal Artificial Tear Pump-reservoirmentioning

confidence: 92%

Lacrimal Duct Occlusion for the Treatment of Dry Eye

Hamano¹

2005

Seminars in Ophthalmology

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The most widespread treatment for dry eyes in clinical practice is an instillation containing artificial tear fluid. When an instillation does not ameliorate dry eye, we use punctal plugs. The insertion of punctal plugs is an eminent curative that positively improves the corneal and conjunctival epithelial disorders and the amount of lacrimal fluid accumulated in the conjunctival sac. We shall introduce the lacrimal duct occlusion utilizing atelocollagen solutions, which solves many of the issues induced by conventional methods.

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Section: Subcutaneous Abdominal Artificial Tear Pump-reservoirmentioning

confidence: 92%

Lacrimal Duct Occlusion for the Treatment of Dry Eye

Hamano¹

2005

Seminars in Ophthalmology

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“…The use of the pump was associated with significant improvement in the signs and symptoms of dry eye, and the device was well tolerated [45].…”

Section: Tear Pumpsmentioning

confidence: 99%

Recent advances in the management of ocular complications of sjögren’s syndrome

Samarkos

Moutsopoulos

2005

Curr Allergy Asthma Rep

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Sjögren's syndrome (SS) is an autoimmune disorder, the principal ocular manifestation of which is decreased tear production leading to chronic irritation and damage to the corneal and conjunctival epithelium. The most important advance in the treatment of ocular manifestations of SS is the introduction of topical anti-inflammatory agents such as cyclosporine A, which increases tear production and decreases symptoms without any significant side effect. Stimulators of tear secretion, both topical, such as diquafosol, and systemic, such as pilocarpine and cevimeline, are also effective, although they have been associated with frequent side effects. Topical use of autologous serum is another new and effective form of treatment, but problems in the preparations prevent their widespread use. Additionally, nonpharmacologic treatments, such as insertion of punctal plugs, are beneficial in the dry eye of SS, whereas several other modalities, such as anti-CD4 monoclonal antibody eye drops and gene transfer, are still in experimental phases.

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“…In individuals suffering of severe dry eye syndrome, the tear film tends to evaporate in less than a second [23,25], causing a permanent burning sensation, and consequently a critical decrease in vision and life quality. There are devices allowing patients to self-administer artificial tears easily and semi-automatically, they include implants inserted under the skin [26] and devices placed in the conjunctival sac of the eye [27]. Nevertheless, such devices are invasive, prone to contaminates, and may become impractical.…”

Section: Introductionmentioning

confidence: 99%

Control System Applied to the Microinjection of Artificial Tears for Severe Dry Eye Treatment

Meni-Babakidi¹,

Viramontes-Gamboa²,

Ibarra-Bracamontes³

et al. 2020

Applied Sciences

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This paper presents a portable automated teardrop microinjection system as a practical solution for patients suffering from severe dry eye. The electronic device for the controlled and continuous injection of artificial tears is designed, assembled, and tested for performance and stability. It is controlled via Wi-Fi from an Android programmable device. Its design is based on the physicochemical properties of artificial tears, and with both production costs and portability in mind. The system was modeled according to the V methodology of the association for professional German engineers VDI 2206 standard. The microinjector handles a wide range of internal variables such as tears flow rate (0.13 to 60 μL/min), tears viscosity (up to 600 Pa·s), temperature (up to 60 °C), injected volume of tears, and time between consecutive injections. For evaluation purposes, a comprehensive set of experimental tests were carried out to the system, comparing the actually delivered amount of tears, flow rate, and prescribed time vs. programmed values, the error was ∼0.2% for commercially available artificial tears.

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Subcutaneous abdominal artificial tears pump-reservoir for severe dry eye

Cited by 29 publications

References 4 publications

Lacrimal Duct Occlusion for the Treatment of Dry Eye

Lacrimal Duct Occlusion for the Treatment of Dry Eye

Recent advances in the management of ocular complications of sjögren’s syndrome

Control System Applied to the Microinjection of Artificial Tears for Severe Dry Eye Treatment

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