Subcutaneous phaeohyphomycosis from Medicopsis romeroi in a diabetic patient

Chanyachailert, Pattriya; Leeyaphan, Charussri; Bunyaratavej, Sumanas; Chongtrakool, Piriyaporn

doi:10.1016/j.mmcr.2019.07.006

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…These 52 cases corresponded to 38 cases of PHM, including ours [ 1 , 2 , 3 , 4 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ] and 14 cases of eumycetoma [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Two cases published as mycetoma by Thiyagarajan et al and Sum et al [ 20 , 21 ] were classified in this review as PHM, regarding the clinical presentation and the lack of grains and bone involvement.…”

Section: Methodsmentioning

confidence: 88%

“…Subcutaneous PHM is, as shown in our literature review, the most frequently reported clinical presentation (65% of the literature review cases). It is responsible for nodulocystic subcutaneous lesions and abscesses affecting mostly immunocompromised patients with an immunosuppression course ranging from one month to many years [ 1 , 16 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 45 ]. In addition to this typical subcutaneous form of M. romeroi PHM, other presentations were rarely reported, including superficial, disseminated, ocular, and osteoarticular forms.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Subcutaneous Phaeohyphomycosis Due to Medicopsis romeroi: A Case Report in a Dermatomyositis Patient and Review of the Literature

Aljundi¹,

Brun

Akhoundi

et al. 2022

Microorganisms

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Medicopsis romeroi phaeohyphomycosis is increasingly reported in immunocompromised patients living in or originating from tropical and subtropical areas. We report a case of subcutaneous phaeohyphomycosis caused by M. romeroi in a 56-year-old Malian woman residing in France for 20 years. She developed a small nodule on her dominant hand’s ring finger 15 months after starting immunosuppressive medications for paraneoplastic dermatomyositis. A first surgical debridement was followed by a local recurrence. Despite a second surgical excision combined with posaconazole treatment, the infection recurred one year after antifungal therapy discontinuation. A wide excision was performed again, and antifungal therapy was resumed and maintained for six months, resulting in the absence of relapse during the 18 months following the surgery. This case highlighted the high risk of relapse in immunocompromised patients, suggesting the need for long-term follow-up and prolonged antifungal treatment following surgical excision in cases with sustained immunosuppression. The literature review was performed according to PRISMA guidelines and included 51 scientific publications. A noteworthy predominance of the subcutaneous phaeohyphomycosis presentation was found in immunocompromised patients, whereas eumycetoma had been reported in apparently healthy individuals. A combination of complete excision with antifungal treatment seemed to confer the best outcome.

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Section: Methodsmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Recurrent Subcutaneous Phaeohyphomycosis Due to Medicopsis romeroi: A Case Report in a Dermatomyositis Patient and Review of the Literature

Aljundi¹,

Brun

Akhoundi

et al. 2022

Microorganisms

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“…Phaeohyphomycosis is an uncommon fungal infection occurring more commonly in tropical climates such as India 1 . Most cases have been reported in immunocompromised individuals especially, in diabetics, and in post‐transplant settings 2 . The infection usually results from the traumatic implantation of the causative fungal organism into the subcutaneous tissue and deep dermis.…”

Section: Discussionmentioning

confidence: 99%

“…These differential diagnoses must be ruled out with the growth of dematiaceous moulds on culture and species identification by molecular methods, which is confirmatory. 2,6 The treatment options include surgical excision and oral or systemic antifungal therapy. 3 Adequate control of hyperglycaemia is equally important as seen in the index case.…”

Section: Morphology Quizmentioning

confidence: 99%

“…Only FNAC/biopsy is sufficient for diagnosis c. Adequate response to oral antifungals is seen d. Recurrences are uncommon4 | DISCUSS IONPhaeohyphomycosis is an uncommon fungal infection occurring more commonly in tropical climates such as India 1. Most cases have been reported in immunocompromised individuals especially, in diabetics, and in post-transplant settings 2. The infection usually results from the traumatic implantation of the causative fungal organismF I G U R E 1 Fine needle aspiration cytology.…”

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confidence: 99%

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Not all black fungus is mucormycosis: A challenging case of Medicopsis romeroi

et al. 2023

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Subcutaneous phaeohyphomycosis is an uncommon fungal infectionof the dermis and subcutaneous tissues wherein the host immune status is an important variable in its manifestations. Fine needle aspiration cytology (FNAC) and culture sensitivity are useful techniques for the diagnosis of the causative organism. | C A S E REP ORTA 59-year-old female presented with a history of serosanguinous discharge from recurrent subcutaneous swelling over the dorsum of the right hand for 10 months. She had poorly controlled type 2 diabetes mellitus and suffered from COVID-19 infection 2 months back which was managed conservatively. Following the infection, the size of the swelling and discharging sinuses increased. A horizontal scar was also noted for incision and drainage given at a local hospital. No other systemic ailments were noted. The clinical differential diagnoses were mucormycosis, botryomycosis, eumycetoma, actinomycosis, and atypical mycobacteria. FNAC was requested and the swelling was noted to be subcutaneous, poorly defined, firm, and non-tender over the dorsum of the right hand extending to the wrist joint. Multiple discharging sinuses were noted although no

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Classes and phyla of the kingdom Fungi

Wijayawardene,

Hyde,

Mikhailov

et al. 2024

Fungal Diversity

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Fungi are one of the most diverse groups of organisms with an estimated number of species in the range of 2–3 million. The higher-level ranking of fungi has been discussed in the framework of molecular phylogenetics since Hibbett et al., and the definition and the higher ranks (e.g., phyla) of the ‘true fungi’ have been revised in several subsequent publications. Rapid accumulation of novel genomic data and the advancements in phylogenetics now facilitate a robust and precise foundation for the higher-level classification within the kingdom. This study provides an updated classification of the kingdom Fungi, drawing upon a comprehensive phylogenomic analysis of Holomycota, with which we outline well-supported nodes of the fungal tree and explore more contentious groupings. We accept 19 phyla of Fungi, viz. Aphelidiomycota, Ascomycota, Basidiobolomycota, Basidiomycota, Blastocladiomycota, Calcarisporiellomycota, Chytridiomycota, Entomophthoromycota, Entorrhizomycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota, Sanchytriomycota, and Zoopagomycota. In the phylogenies, Caulochytriomycota resides in Chytridiomycota; thus, the former is regarded as a synonym of the latter, while Caulochytriomycetes is viewed as a class in Chytridiomycota. We provide a description of each phylum followed by its classes. A new subphylum, Sanchytriomycotina Karpov is introduced as the only subphylum in Sanchytriomycota. The subclass Pneumocystomycetidae Kirk et al. in Pneumocystomycetes, Ascomycota is invalid and thus validated. Placements of fossil fungi in phyla and classes are also discussed, providing examples.

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Subcutaneous phaeohyphomycosis from Medicopsis romeroi in a diabetic patient

Cited by 10 publications

References 13 publications

Recurrent Subcutaneous Phaeohyphomycosis Due to Medicopsis romeroi: A Case Report in a Dermatomyositis Patient and Review of the Literature

Recurrent Subcutaneous Phaeohyphomycosis Due to Medicopsis romeroi: A Case Report in a Dermatomyositis Patient and Review of the Literature

Not all black fungus is mucormycosis: A challenging case of Medicopsis romeroi

Classes and phyla of the kingdom Fungi

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